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Advanced filters: Author: Bi-Qing Chen Clear advanced filters

Whole-brain in vivo base editing reverses behavioral changes in Mef2c-mutant mice

Li et al. developed a base-editing system to edit mutations linked to autism. Targeting a mutation in Mef2c restored Mef2c protein levels in several brain regions and reversed behavioral changes in Mef2c-mutant mice.

Wei-Ke Li
Shu-Qian Zhang
Zi-Long Qiu
Research27 Nov 2023
Nature Neuroscience

Volume: 27, P: 116-128
Increased NRG1-ErbB4 signaling in human symptomatic epilepsy

Jun-Ming Zhu
Ke-Xin Li
Xiao-Ming Li
ResearchOpen Access10 Mar 2017
Scientific Reports

Volume: 7, P: 1-7

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Whole-brain in vivo base editing reverses behavioral changes in Mef2c-mutant mice

Increased NRG1-ErbB4 signaling in human symptomatic epilepsy

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