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Showing 1–5 of 5 results
Advanced filters: Author: Bi-Xing Chen Clear advanced filters

  • TR3 is an orphan nuclear receptor with roles in apoptosis. A TR3-binding compound induces mitochondrial translocation of TR3 and autophagy via the Nix–Toms–ANT1/VDAC1 pathway, providing a mechanism for cell death in melanoma cells that are resistant to spontaneous and drug-induced apoptosis.

    • Wei-jia Wang
    • Yuan Wang
    • Qiao Wu
    Research
    Nature Chemical Biology
    Volume: 10, P: 133-140

  • Papa et al. show that phosphorylation by PKA of four residues in Rad, a calcium channel inhibitor, is required to mediate the β-adrenergic-induced increase in calcium current and contractile force. Additionally, Rad-phosphosite-mutant mice showed reduced basal heart rate and contractility. Conversely, expression of mutant calcium channel unable to bind wild-type or phosphosite-mutant Rad was sufficient to enhance basal calcium influx and contractility, independently of β-adrenergic stimulation.

    • Arianne Papa
    • Sergey I. Zakharov
    • Steven O. Marx
    ResearchOpen Access
    Nature Cardiovascular Research
    Volume: 1, P: 1022-1038

  • Increased late sodium current due to the disruption of voltage-gated sodium channel inactivation is a common pathogenic mechanism in different arrhythmogenic syndromes. Chakouri et al. show that fibroblast growth factor homologous factors (FHFs) modulate pathogenic late sodium current in an isoform-specific way, and leverage this observation to design and test a prototype of inhibitor peptide based on a protein domain from an inhibitory FHF isoform.

    • Nourdine Chakouri
    • Sharen Rivas
    • Manu Ben-Johny
    Research
    Nature Cardiovascular Research
    Volume: 1, P: 1-13

  • An in vivo approach to identify proteins whose enrichment near cardiac CaV1.2 channels changes upon β-adrenergic stimulation finds the G protein Rad, which is phosphorylated by protein kinase A, thereby relieving channel inhibition by Rad and causing an increased Ca2+ current.

    • Guoxia Liu
    • Arianne Papa
    • Steven O. Marx
    Research
    Nature
    Volume: 577, P: 695-700