Nature Search

Unveiling RNA structure-mediated regulations of RNA stability in wheat

This study shows that mRNA decay in durum wheat is affected by 3’ UTR structures and domestication-selected single-nucleotide variations, highlighting the importance of non-coding regions in gene expression and the potential for crop enhancement.

Haidan Wu
Haopeng Yu
Huakun Zhang
ResearchOpen Access20 Nov 2024
Nature Communications

Volume: 15, P: 1-14
Integrating electronic health records and GWAS summary statistics to predict the progression of autoimmune diseases from preclinical stages

The authors propose a Genetic Progression Score (GPS) model to predict autoimmune disease progression from preclinical stages, integrating genome-wide association study summary statistics and electronic health records from the All of Us and BioVU biobanks.

Chen Wang
Havell Markus
Bibo Jiang
ResearchOpen Access02 Jan 2025
Nature Communications

Volume: 16, P: 1-17
Enhancing pharmacokinetic properties of Chikusetsusaponin IVa via modification of polyethylenimine/poly(lactic-co-glycolic acid) nanoparticles for sustained drug delivery

Xiaohong Zheng
Bibo Li
Guangxiu Cao
ResearchOpen Access02 Dec 2025
Scientific Reports

Volume: 16, P: 1-15
Multi-ancestry and multi-trait genome-wide association meta-analyses inform clinical risk prediction for systemic lupus erythematosus

The genetic basis of systemic lupus erythematosus is not completely understood. Here, the authors perform multi-ancestry and multi-trait meta-analyses to identify 16 novel genetic loci and demonstrate the utility of polygenic risk score in clinical risk prediction when used with conventional lab tests.

Chachrit Khunsriraksakul
Qinmengge Li
Dajiang J. Liu
ResearchOpen Access07 Feb 2023
Nature Communications

Volume: 14, P: 1-14
Realizing the symmetry-protected Haldane phase in Fermi–Hubbard ladders

A ladder-like arrangement of an ultracold gas of lithium atoms trapped in an optical lattice enables the observation of a symmetry-protected topological phase.

Pimonpan Sompet
Sarah Hirthe
Immanuel Bloch
ResearchOpen Access01 Jun 2022
Nature

Volume: 606, P: 484-488
MoleProLink-RL: geometric transport for domain-policy reinforcement learning in drug-target interaction prediction

Donghao Xu
Bibo Wang
Chao Zhang
ResearchOpen Access24 Nov 2025
npj Digital Medicine

Volume: 8, P: 1-11
Genetic diversity fuels gene discovery for tobacco and alcohol use

A multi-ancestry meta-regression study analyses diverse genome-wide association studies and genome loci associated with tobacco and alcohol use.

Gretchen R. B. Saunders
Xingyan Wang
Scott Vrieze
ResearchOpen Access07 Dec 2022
Nature

Volume: 612, P: 720-724
Effect of ultrasonic burst microbubbles on microwave coagulation hemostasis in a pig model of hepatic hemorrhage

Bibo Peng
Shengnan Li
Lina An
ResearchOpen Access18 Feb 2025
Scientific Reports

Volume: 15, P: 1-8
The RRM-mediated RNA binding activity in T. brucei RAP1 is essential for VSG monoallelic expression

Monoallelic VSG expression is essential for Trypanosoma brucei survival. Competition between TbRAP1’s RNA and dsDNA binding activities ensures that TbRAP1 sustains a high level expression of the active VSG while silencing other VSGs globally.

Amit Kumar Gaurav
Marjia Afrin
Bibo Li
ResearchOpen Access22 Mar 2023
Nature Communications

Volume: 14, P: 1-14
Dissecting heritability, environmental risk, and air pollution causal effects using > 50 million individuals in MarketScan

Large national-level electronic health record datasets offer new opportunities for disentangling the roles of genes and environment in human diseases. Here, the authors propose a spatial mixed linear effect model (SMILE) to dissect genetic and environmental risk factors for diseases and assess the causality of air pollutants in an insurance claim dataset with 50 million individuals.

Daniel McGuire
Havell Markus
Bibo Jiang
ResearchOpen Access25 Jun 2024
Nature Communications

Volume: 15, P: 1-14
Model-based assessment of replicability for genome-wide association meta-analysis

In genome-wide association meta-analysis, it is often difficult to find an independent dataset of sufficient size to replicate associations. Here, the authors have developed MAMBA to calculate the probability of replicability based on consistency between datasets within the meta-analysis.

Daniel McGuire
Yu Jiang
Dajiang J. Liu
ResearchOpen Access30 Mar 2021
Nature Communications

Volume: 12, P: 1-14
A subset of type-II collagen-binding antibodies prevents experimental arthritis by inhibiting FCGR3 signaling in neutrophils

Rheumatoid arthritis (RA) involves several types of autoantibodies, which are usually considered pathogenic. In this study, the authors use phage display to develop antibodies targeting type-II collagen that are protective in multiple experimental models of RA.

Zhongwei Xu
Bingze Xu
Rikard Holmdahl
ResearchOpen Access23 Sept 2023
Nature Communications

Volume: 14, P: 1-14
Author Correction: APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes

Joel W. Blanchard
Leyla Anne Akay
Li-Huei Tsai
Amendments and Corrections04 Dec 2024
Nature

Volume: 636, P: E9
A subset of antibodies targeting citrullinated proteins confers protection from rheumatoid arthritis

Although anti-citrullinated protein antibodies (ACPAs) are a hallmark of rheumatoid arthritis and generally considered pathogenic, their functional relevance is incompletely understood. In this study, the authors describe an ACPA with a protective effect against antibody-induced arthritis in mice.

Yibo He
Changrong Ge
Rikard Holmdahl
ResearchOpen Access08 Feb 2023
Nature Communications

Volume: 14, P: 1-19
APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes

APOE4 is associated with widespread gene expression changes across all cell types of the human brain, altered cholesterol homeostasis and transport signalling pathways, and decreased myelination in the brain.

Joel W. Blanchard
Leyla Anne Akay
Li-Huei Tsai
Research16 Nov 2022
Nature

Volume: 611, P: 769-779
Characterization of the genomic landscape and actionable mutations in Chinese breast cancers by clinical sequencing

Chinese breast cancer patients have not been well represented in clinical sequencing studies. Here the authors analyse the mutational landscape of 1,134 Chinese breast cancer patients, finding actionable targets and a higher prevalence of p53 and Hippo pathway mutations compared to Western cohorts.

Guan-Tian Lang
Yi-Zhou Jiang
Zhi-Ming Shao
ResearchOpen Access10 Nov 2020
Nature Communications

Volume: 11, P: 1-13
Laser-driven luminescent ceramic-converted near-infrared II light source for advanced imaging and detection techniques

TOC: Images of polished MgO:x%Ni²⁺, y%Cr³⁺ (x = 0-0.7, y = 0 and 0.3) ceramics under natural light and NIR-II output power of laser-driven NIR-II device based on MgO:x%Ni²⁺, 0.3%Cr³⁺ (x = 0.1-0.7) ceramics under different incident blue laser power densities. This work paves a new avenue for the future development of high-performance Ni²⁺-activated NIR-II emissive luminescence ceramics for laser-driven non-destructive real-time high-power NIR-II imaging and detection applications.

Simin Gu
Huiwang Lian
Jing Wang
ResearchOpen Access11 Sept 2025
Light: Science & Applications

Volume: 14, P: 1-10
Telomere structure and function in trypanosomes: a proposal

Telomeres are specialized DNA–protein complexes that are required for protection and replication of chromosome ends. In this Opinion, George Cross and colleagues discuss the biology of telomere function in trypanosomes and propose an intriguing role for these structures in regulating antigenic variation.

Oliver Dreesen
Bibo Li
George A. M. Cross
Reviews11 Dec 2006
Nature Reviews Microbiology

Volume: 5, P: 70-75
Preliminary studies on differential defense responses induced during plant communication

Jin Ying PENG
Zhong Hai LI
Yong Ping HUANG
Research01 Mar 2005
Cell Research

Volume: 15, P: 187-192
Morphological and proteomic study of waterlogging tolerance in cotton

Hao Zhang
Zhangshu Xie
Zhonghua Zhou
ResearchOpen Access24 Jun 2024
Scientific Reports

Volume: 14, P: 1-12
Investigation of multimorbidity patterns and association rules in patients with type 2 diabetes mellitus using association rules mining algorithm

Lianhua Liu
Xiaodan Wang
Bo Bi
ResearchOpen Access16 Jul 2025
Scientific Reports

Volume: 15, P: 1-14
Moving beyond neurons: the role of cell type-specific gene regulation in Parkinson’s disease heritability

Regina H. Reynolds
Juan Botía
Mina Ryten
ResearchOpen Access17 Apr 2019
npj Parkinson's Disease

Volume: 5, P: 1-14
The Foxo1-YAP-Notch1 axis reprograms STING-mediated innate immunity in NASH progression

Dongwei Xu
Xiaoye Qu
Bibo Ke
ResearchOpen Access09 Aug 2024
Experimental & Molecular Medicine

Volume: 56, P: 1843-1855
A convenient polyculture system that controls a shrimp viral disease with a high transmission rate

Wang et al. develop a shrimp polyculture system that prevents white spot syndrome outbreaks by introducing specific fish species. The system is easy to implement and requires no special biosecurity measures which makes it ideal for small-scale farmers.

Muhua Wang
Yonggui Chen
Jianguo He
ResearchOpen Access11 Nov 2021
Communications Biology

Volume: 4, P: 1-11
Telomerase activity is required for the telomere G-overhang structure in Trypanosoma brucei

Ranjodh Sandhu
Bibo Li
ResearchOpen Access22 Nov 2017
Scientific Reports

Volume: 7, P: 1-13
Jagged1-mediated myeloid Notch1 signaling activates HSF1/Snail and controls NLRP3 inflammasome activation in liver inflammatory injury

Yuting Jin
Changyong Li
Bibo Ke
ResearchOpen Access31 Oct 2019
Cellular & Molecular Immunology

Volume: 17, P: 1245-1256
Functional crosstalk between myeloid Foxo1–β-catenin axis and Hedgehog/Gli1 signaling in oxidative stress response

Changyong Li
Mingwei Sheng
Bibo Ke
ResearchOpen Access07 Dec 2020
Cell Death & Differentiation

Volume: 28, P: 1705-1719
Loss of ATF3 exacerbates liver damage through the activation of mTOR/p70S6K/ HIF-1α signaling pathway in liver inflammatory injury

Qiang Zhu
Han Wang
Ling Lu
ResearchOpen Access05 Sept 2018
Cell Death & Disease

Volume: 9, P: 1-13
Selectin-Mediated Interactions Regulate Cytokine Networks and Macrophage Heme Oxygenase-1 Induction in Cardiac Allograft Recipients

Ana J Coito
Gray D Shaw
Jerzy W Kupiec-Weglinski
Research01 Jan 2002
Laboratory Investigation

Volume: 82, P: 61-70
Transcriptional regulation of miR-15b by c-Rel and CREB in Japanese encephalitis virus infection

Bibo Zhu
Jing Ye
Shengbo Cao
ResearchOpen Access02 Mar 2016
Scientific Reports

Volume: 6, P: 1-15
Dynamics of the Transcriptome during Human Spermatogenesis: Predicting the Potential Key Genes Regulating Male Gametes Generation

Zijue Zhu
Chong Li
Zheng Li
ResearchOpen Access12 Jan 2016
Scientific Reports

Volume: 6, P: 1-15
A trans-spliced telomerase RNA dictates telomere synthesis in Trypanosoma brucei

Ranjodh Sandhu
Samantha Sanford
Kausik Chakrabarti
Research12 Mar 2013
Cell Research

Volume: 23, P: 537-551
Skill complementarity enhances heterophily in collaboration networks

Wen-Jie Xie
Ming-Xia Li
H. Eugene Stanley
ResearchOpen Access08 Jan 2016
Scientific Reports

Volume: 6, P: 1-9
Trypanosoma brucei TIF2 suppresses VSG switching by maintaining subtelomere integrity

Sanaa E Jehi
Fan Wu
Bibo Li
Research09 May 2014
Cell Research

Volume: 24, P: 870-885

Search

Unveiling RNA structure-mediated regulations of RNA stability in wheat

Integrating electronic health records and GWAS summary statistics to predict the progression of autoimmune diseases from preclinical stages

Enhancing pharmacokinetic properties of Chikusetsusaponin IVa via modification of polyethylenimine/poly(lactic-co-glycolic acid) nanoparticles for sustained drug delivery

Multi-ancestry and multi-trait genome-wide association meta-analyses inform clinical risk prediction for systemic lupus erythematosus

Realizing the symmetry-protected Haldane phase in Fermi–Hubbard ladders

MoleProLink-RL: geometric transport for domain-policy reinforcement learning in drug-target interaction prediction

Genetic diversity fuels gene discovery for tobacco and alcohol use

Effect of ultrasonic burst microbubbles on microwave coagulation hemostasis in a pig model of hepatic hemorrhage

The RRM-mediated RNA binding activity in T. brucei RAP1 is essential for VSG monoallelic expression

Dissecting heritability, environmental risk, and air pollution causal effects using > 50 million individuals in MarketScan

Model-based assessment of replicability for genome-wide association meta-analysis

A subset of type-II collagen-binding antibodies prevents experimental arthritis by inhibiting FCGR3 signaling in neutrophils

Author Correction: APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes

A subset of antibodies targeting citrullinated proteins confers protection from rheumatoid arthritis

APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes

Characterization of the genomic landscape and actionable mutations in Chinese breast cancers by clinical sequencing

Laser-driven luminescent ceramic-converted near-infrared II light source for advanced imaging and detection techniques

Telomere structure and function in trypanosomes: a proposal

Preliminary studies on differential defense responses induced during plant communication

Morphological and proteomic study of waterlogging tolerance in cotton

Investigation of multimorbidity patterns and association rules in patients with type 2 diabetes mellitus using association rules mining algorithm

Moving beyond neurons: the role of cell type-specific gene regulation in Parkinson’s disease heritability

The Foxo1-YAP-Notch1 axis reprograms STING-mediated innate immunity in NASH progression

A convenient polyculture system that controls a shrimp viral disease with a high transmission rate

Telomerase activity is required for the telomere G-overhang structure in Trypanosoma brucei

Jagged1-mediated myeloid Notch1 signaling activates HSF1/Snail and controls NLRP3 inflammasome activation in liver inflammatory injury

Functional crosstalk between myeloid Foxo1–β-catenin axis and Hedgehog/Gli1 signaling in oxidative stress response

Loss of ATF3 exacerbates liver damage through the activation of mTOR/p70S6K/ HIF-1α signaling pathway in liver inflammatory injury

Selectin-Mediated Interactions Regulate Cytokine Networks and Macrophage Heme Oxygenase-1 Induction in Cardiac Allograft Recipients

Transcriptional regulation of miR-15b by c-Rel and CREB in Japanese encephalitis virus infection

Dynamics of the Transcriptome during Human Spermatogenesis: Predicting the Potential Key Genes Regulating Male Gametes Generation

A trans-spliced telomerase RNA dictates telomere synthesis in Trypanosoma brucei

Skill complementarity enhances heterophily in collaboration networks

Trypanosoma brucei TIF2 suppresses VSG switching by maintaining subtelomere integrity

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