Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–3 of 3 results
Advanced filters: Author: Biff Forbush Clear advanced filters

  • Loop diuretics including bumetanide inhibit Na+-K+-Cl−-cotransporters (NKCCs) and are used for the treatment of edema and hypertension. Here, Zhao et. al. report structures of NKCC1 with bumetanide bound, revealing its mechanism of action that would facilitate design of novel diuretics.

    • Yongxiang Zhao
    • Kasturi Roy
    • Erhu Cao
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-12

  • The Na+-Cl− cotransporter (NCC) drives salt reabsorption in the kidney. Here the authors determine NCC co-structures individually complexed with the thiazide drug hydrochlorothiazide, and two thiazide-like drugs chlorthalidone and indapamide, revealing that they occlude the NCC ion translocation pathway.

    • Yongxiang Zhao
    • Heidi Schubert
    • Erhu Cao
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13

  • Zhang et al. present the cryo-electron microscopy structures of the two neuronal cation-chloride cotransporters human NKCC1 and mouse KCC2, identifying their essential residues for ion transport. This study proposes mechanisms by which phosphorylation regulates the activity of these cation-chloride cotransporters.

    • Sensen Zhang
    • Jun Zhou
    • Maojun Yang
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-15