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Stem cell-derived polarized hepatocytes

To model hepatocyte function accurately in vitro, it is necessary to generate and maintain a polarized epithelium. Here, the authors describe a protocol to generate polarized human pluripotent stem cell-derived hepatocyte-like cells (HLCs) to model enteric virus production and drug secretion in vitro.

Viet Loan Dao Thi
Xianfang Wu
Charles M. Rice
ResearchOpen Access03 Apr 2020
Nature Communications

Volume: 11, P: 1-13
Differential efficacy of first licensed western vaccines protecting without immunopathogenesis Wuhan-1-challenged hamsters from severe COVID-19

Aileen Ebenig
Mona V. Lange
Michael D. Mühlebach
ResearchOpen Access17 Mar 2025
npj Vaccines

Volume: 10, P: 1-11
Restrictive influence of SAMHD1 on Hepatitis B Virus life cycle

Andreas F. R. Sommer
Lise Rivière
Renate König
ResearchOpen Access27 May 2016
Scientific Reports

Volume: 6, P: 1-14