The molecular mechanism of LAP activation against invading pathogens is not fully understood. Here the authors demonstrate that programmed cell death 6 (PDCD6) negatively regulates LAP formation and the antibacterial response by interacting with lactate dehydrogenase A (LDHA) to downregulate lactate metabolism and RUBCN lactylation-mediated signaling.
- Lulu Sun
- Sijin Wu
- Tianliang Li
