Nature Search

Pantothenate kinase 2 interacts with PINK1 to regulate mitochondrial quality control via acetyl-CoA metabolism

PKAN and PD are two distinct diseases with overlapping pathophysiology. Here, authors show that their pathogenic genes PANK2 and PINK1 interact. PANK2 regulates mitophagy via CoA metabolism, while PINK1 supervises PANK2 translation on mitochondria.

Yunpeng Huang
Zhihui Wan
Bing Zhou
ResearchOpen Access03 May 2022
Nature Communications

Volume: 13, P: 1-16
Direct in-situ insights into the asymmetric surface reconstruction of rutile TiO₂ (110)

The reconstruction of rutile TiO2 (110) impacts its surface chemistry and catalytic properties. Here, the authors offer a detailed understanding of the asymmetric surface reconstruction of TiO2 (110)-(1×2) through a combination of STEM and DFT calculations.

Wentao Yuan
Bingwei Chen
Yong Wang
ResearchOpen Access22 Feb 2024
Nature Communications

Volume: 15, P: 1-7
Heteroaromatic π-stacking engineered near-infrared absorption for highly stable near-zero transmittance electrochromic window

Electrochromic materials have been used in thermal management systems though it is challenging due to limited NIR and long-term instability. Here the authors design an electrochromic organogel for stable electrochromic windows.

Xilu Wu
Bingwei Bao
Hongzhi Wang
ResearchOpen Access12 Nov 2025
Nature Communications

Volume: 16, P: 1-10
Aromatic C-H addition of ketones to imines enabled by manganese catalysis

The Mannich reaction proceeds by functionalization of C(sp³)-H bonds alpha to carbonyls. Here, the authors suppress the Mannich reactivity of acetophenones in presence of a manganese catalyst and obtain valuable o-aminoalkylacetophenones and isoindolines via C(sp²)-H functionalization with imines.

Bingwei Zhou
Yuanyuan Hu
Congyang Wang
ResearchOpen Access27 Oct 2017
Nature Communications

Volume: 8, P: 1-9
ECSIT facilitates memory CD8⁺ T cell development by mediating fumarate synthesis during viral infection and tumorigenesis

Yang et al. identify an essential role for ECSIT in promoting memory CD8⁺ T cell development by modulating fumarate synthesis and altering TCF-1 activity, thereby impacting host responses during viral infection and tumorigenesis.

Yongbing Yang
Yanan Wang
Shuo Yang
Research07 Feb 2024
Nature Cell Biology

Volume: 26, P: 450-463
Polo inhibits progenitor self-renewal and regulates Numb asymmetry by phosphorylating Pon

The mitotic kinase Polo regulates the asymmetric localization of the tumour-suppressor protein Numb through phosphorylating Pon, the adaptor protein for Numb, and Polo acts as a tumour-suppressor through regulating Pon/Numb. This provides the first direct biochemical link between the cell cycle and asymmetric protein localization machinery and reveals a novel mechanism underlying the tumour suppressor function of Polo.

Hongyan Wang
Yingshi Ouyang
Bingwei Lu
Research06 Sept 2007
Nature

Volume: 449, P: 96-100
Phospho-dependent ubiquitination and degradation of PAR-1 regulates synaptic morphology and tau-mediated Aβ toxicity in Drosophila

PAR-1 inDrosophilahas been identified as a key physiological tau kinase. Lee and colleagues perform genetic screens for regulators of PAR-1 and find that it is targeted for ubiquitination and degradation by the ubiquitin ligase complex SCF(Slimb), and that this pathway modulates synaptic morphology.

Seongsoo Lee
Ji-Wu Wang
Bingwei Lu
Research27 Dec 2012
Nature Communications

Volume: 3, P: 1-12
Unique Genetic Characteristics and Clinical Prognosis of Female Patients with Lung Cancer Harboring RET Fusion Gene

Zhixin Qiu
Bingwei Ye
Panwen Tian
ResearchOpen Access25 Jun 2020
Scientific Reports

Volume: 10, P: 1-9
Low 25-hydroxyvitamin D is associated with arterial stiffness in Chinese with Type 2 diabetes mellitus

Bingwei Ma
Yao Chen
Shen Qu
Research31 Mar 2021
European Journal of Clinical Nutrition

Volume: 75, P: 1645-1653
Oxygen/phosphorus co-doped porous carbon from cicada slough as high-performance electrode material for supercapacitors

Bingwei Chen
Wenzhuo Wu
Yuping Wu
ResearchOpen Access01 Apr 2019
Scientific Reports

Volume: 9, P: 1-8
Minimizing the electrosorption of water from humid ionic liquids on electrodes

Ionic liquid electrolytes can impart increased operational voltage and energy density in supercapacitors, but water may diminish performance. Here the authors show that the hydrophilicity/hydrophobicity of ionic liquids can influence electrosorption of water and ultimately the supercapacitor performance.

Sheng Bi
Runxi Wang
Guang Feng
ResearchOpen Access04 Dec 2018
Nature Communications

Volume: 9, P: 1-9
A lithium ion battery using an aqueous electrolyte solution

Zheng Chang
Chunyang Li
Wei Huang
ResearchOpen Access22 Jun 2016
Scientific Reports

Volume: 6, P: 1-6
CoCO₃ from one-step micro-emulsion method as electrode materials for Faradaic capacitors

Yanfang Wang
Zheng Chang
Yuping Wu
ResearchOpen Access17 May 2017
Scientific Reports

Volume: 7, P: 1-8
The E3 ubiquitin ligase Pellino2 mediates priming of the NLRP3 inflammasome

The NLRP3 inflammasome is important for inducing IL-1β and IL-18 inflammatory responses. Here the authors show, by generating and characterizing Peli2 deficient mice and immune cells, that an E3 ubiquitin ligase Pellino2 promotes inflammasome priming by inducing NLRP3 ubiquitination and by targeting IRAK1.

Fiachra Humphries
Ronan Bergin
Paul N. Moynagh
ResearchOpen Access19 Apr 2018
Nature Communications

Volume: 9, P: 1-17
Pellino3 targets RIP1 and regulates the pro-apoptotic effects of TNF-α

Pellino family proteins are ubiquitin ligases known to regulate immune signalling. Here Yang et al. show that Pellino3 regulates apoptotic TNF signalling by modulating the composition of the death-induced signalling complex, and that absence of Pellino3 sensitizes mice to TNF.

Shuo Yang
Bingwei Wang
Paul N. Moynagh
Research11 Oct 2013
Nature Communications

Volume: 4, P: 1-19
Pellino3 targets the IRF7 pathway and facilitates autoregulation of TLR3- and viral-induced expression of type I interferons

Signaling through toll-like receptors induces cytokines and type I interferon. Moynagh and colleagues show that the E3 ubiquitin ligase Pellino3 specifically represses the expression of type I interferon in response to TLR3 activation.

Jakub Siednienko
Ruaidhri Jackson
Paul N Moynagh
Research07 Oct 2012
Nature Immunology

Volume: 13, P: 1055-1062
Pellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and protective effects in colitis

The E3 ubiquitin ligases that modify the kinase RIP2 downstream of the receptor Nod2 remain unclear. Moynagh and colleagues show that Pellino3 ubiquitinates RIP2 for Nod2-induced activation of the transcription factor NF-κB.

Shuo Yang
Bingwei Wang
Paul N Moynagh
Research28 Jul 2013
Nature Immunology

Volume: 14, P: 927-936
Application of FCEEMD-TSMFDE and adaptive CatBoost in fault diagnosis of complex variable condition bearings

Min Mao
Bingwei Xu
Jingzong Yang
ResearchOpen Access16 Dec 2024
Scientific Reports

Volume: 14, P: 1-30
Construction of leadership competency model for civil aviation flight cadets: An empirical study from China

Chen Lin
Liu Bingwei
Wang Yanqing
ResearchOpen Access13 Apr 2025
Scientific Reports

Volume: 15, P: 1-34
BcatrB mediates pyrimethanil resistance in Botrytis cinerea revealed by transcriptomics analysis

Shuqi Wang
Xinyi Zhang
Yong Li
ResearchOpen Access03 Apr 2025
Scientific Reports

Volume: 15, P: 1-14
Correction: Bone morphogenetic protein 4 alleviates nonalcoholic steatohepatitis by inhibiting hepatic ferroptosis

Xingchun Wang
Bingwei Ma
Shen Qu
Amendments and CorrectionsOpen Access24 Nov 2022
Cell Death Discovery

Volume: 8, P: 1-4
DA-DRD5 signaling controls colitis by regulating colonic M1/M2 macrophage polarization

Lu Liu
Yuqing Wu
Shuo Yang
ResearchOpen Access17 May 2021
Cell Death & Disease

Volume: 12, P: 1-17
Integrated plasma metabolomics and lipidomics profiling highlight distinctive signatures with hashimoto’s thyroiditis

Guoqiang Wang
Xuan Ye
Hui Xiao
ResearchOpen Access01 Jul 2025
Scientific Reports

Volume: 15, P: 1-16
Bone morphogenetic protein 4 alleviates nonalcoholic steatohepatitis by inhibiting hepatic ferroptosis

Xingchun Wang
Bingwei Ma
Shen Qu
ResearchOpen Access27 Apr 2022
Cell Death Discovery

Volume: 8, P: 1-10
Development and validation of a nomogram to predict the prognosis of patients with gastric cardia cancer

Xiuquan Shi
Lijun Xu
Siben Wang
ResearchOpen Access24 Aug 2020
Scientific Reports

Volume: 10, P: 1-11
Comparative Effectiveness of Di'ao Xin Xue Kang Capsule and Compound Danshen Tablet in Patients With Symptomatic Chronic Stable Angina

Yanan Yu
Siyuan Hu
Yongyan Wang
ResearchOpen Access14 Nov 2014
Scientific Reports

Volume: 4, P: 1-8
Screening of efficient siRNA carriers in a library of surface-engineered dendrimers

Hongmei Liu
Hong Chang
Yiyun Cheng
ResearchOpen Access28 Apr 2016
Scientific Reports

Volume: 6, P: 1-11
Microbial biomarker discovery in Parkinson’s disease through a network-based approach

Zhe Zhao
Jing Chen
Junliang Yuan
ResearchOpen Access26 Oct 2024
npj Parkinson's Disease

Volume: 10, P: 1-11
Correction to: Low 25-hydroxyvitamin D is associated with arterial stiffness in Chinese with Type 2 diabetes mellitus

Bingwei Ma
Yao Chen
Shen Qu
Amendments and Corrections12 May 2022
European Journal of Clinical Nutrition

Volume: 76, P: 1630
Suppressive effect of exogenous carbon monoxide on endotoxin-stimulated platelet over-activation via the glycoprotein-mediated PI3K-Akt-GSK3β pathway

Dadong Liu
Xu Wang
Bingwei Sun
ResearchOpen Access29 Mar 2016
Scientific Reports

Volume: 6, P: 1-14
The DJ1-Nrf2-STING axis mediates the neuroprotective effects of Withaferin A in Parkinson’s disease

Miao Zhao
Bingwei Wang
Ruimao Zheng
ResearchOpen Access24 Mar 2021
Cell Death & Differentiation

Volume: 28, P: 2517-2535
PKA-RIIβ autophosphorylation modulates PKA activity and seizure phenotypes in mice

Jingliang Zhang et al. examine how dysfunctional PKA signaling impacts neuronal activity and seizure susceptibility in a mouse model of temporal lobe epilepsy. Their data suggest that autophosphorylation of the RIIβ subunit regulates neuronal excitability, and may act as a future therapeutic target.

Jingliang Zhang
Chenyu Zhang
Zhuo Huang
ResearchOpen Access01 Mar 2021
Communications Biology

Volume: 4, P: 1-14
Functional status of microvascular vasomotion is impaired in spontaneously hypertensive rat

Mingming Liu
Xiaoyan Zhang
Ruijuan Xiu
ResearchOpen Access06 Dec 2017
Scientific Reports

Volume: 7, P: 1-14

Search

Pantothenate kinase 2 interacts with PINK1 to regulate mitochondrial quality control via acetyl-CoA metabolism

Direct in-situ insights into the asymmetric surface reconstruction of rutile TiO₂ (110)

Heteroaromatic π-stacking engineered near-infrared absorption for highly stable near-zero transmittance electrochromic window

Aromatic C-H addition of ketones to imines enabled by manganese catalysis

ECSIT facilitates memory CD8⁺ T cell development by mediating fumarate synthesis during viral infection and tumorigenesis

Polo inhibits progenitor self-renewal and regulates Numb asymmetry by phosphorylating Pon

Phospho-dependent ubiquitination and degradation of PAR-1 regulates synaptic morphology and tau-mediated Aβ toxicity in Drosophila

Unique Genetic Characteristics and Clinical Prognosis of Female Patients with Lung Cancer Harboring RET Fusion Gene

Low 25-hydroxyvitamin D is associated with arterial stiffness in Chinese with Type 2 diabetes mellitus

Oxygen/phosphorus co-doped porous carbon from cicada slough as high-performance electrode material for supercapacitors

Minimizing the electrosorption of water from humid ionic liquids on electrodes

A lithium ion battery using an aqueous electrolyte solution

CoCO₃ from one-step micro-emulsion method as electrode materials for Faradaic capacitors

The E3 ubiquitin ligase Pellino2 mediates priming of the NLRP3 inflammasome

Pellino3 targets RIP1 and regulates the pro-apoptotic effects of TNF-α

Pellino3 targets the IRF7 pathway and facilitates autoregulation of TLR3- and viral-induced expression of type I interferons

Pellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and protective effects in colitis

Application of FCEEMD-TSMFDE and adaptive CatBoost in fault diagnosis of complex variable condition bearings

Construction of leadership competency model for civil aviation flight cadets: An empirical study from China

BcatrB mediates pyrimethanil resistance in Botrytis cinerea revealed by transcriptomics analysis

Correction: Bone morphogenetic protein 4 alleviates nonalcoholic steatohepatitis by inhibiting hepatic ferroptosis

DA-DRD5 signaling controls colitis by regulating colonic M1/M2 macrophage polarization

Integrated plasma metabolomics and lipidomics profiling highlight distinctive signatures with hashimoto’s thyroiditis

Bone morphogenetic protein 4 alleviates nonalcoholic steatohepatitis by inhibiting hepatic ferroptosis

Development and validation of a nomogram to predict the prognosis of patients with gastric cardia cancer

Comparative Effectiveness of Di'ao Xin Xue Kang Capsule and Compound Danshen Tablet in Patients With Symptomatic Chronic Stable Angina

Screening of efficient siRNA carriers in a library of surface-engineered dendrimers

Microbial biomarker discovery in Parkinson’s disease through a network-based approach

Correction to: Low 25-hydroxyvitamin D is associated with arterial stiffness in Chinese with Type 2 diabetes mellitus

Suppressive effect of exogenous carbon monoxide on endotoxin-stimulated platelet over-activation via the glycoprotein-mediated PI3K-Akt-GSK3β pathway

The DJ1-Nrf2-STING axis mediates the neuroprotective effects of Withaferin A in Parkinson’s disease

PKA-RIIβ autophosphorylation modulates PKA activity and seizure phenotypes in mice

Functional status of microvascular vasomotion is impaired in spontaneously hypertensive rat

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