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Showing 1–3 of 3 results

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A TFEB–TGFβ axis systemically regulates diapause, stem cell resilience and protects against a senescence-like state

Nonninger et al. identify the TFEB–TGFβ signaling axis as a regulator of stem cell resilience that protects against a senescence-like state during the adult diapause in Caenorhabditis elegans, a mechanism conserved in vertebrate aging and mammalian cancer.

Tim J. Nonninger
Jennifer Mak
Adam Antebi
ResearchOpen Access30 Jun 2025
Nature Aging

Volume: 5, P: 1340-1357
The dynamic nature of netrin-1 and the structural basis for glycosaminoglycan fragment-induced filament formation

In this work, the authors report that heparin oligosaccharides have a significant impact on the highly dynamic behaviour of netrin-1 by inducing hierarchical and distinct super assemblies leading to unique, yet unknown netrin-1 filament formation.

Markus Meier
Monika Gupta
Jörg Stetefeld
ResearchOpen Access03 Mar 2023
Nature Communications

Volume: 14, P: 1-18
NFYB-1 regulates mitochondrial function and longevity via lysosomal prosaposin

Tharyan et al. identify NFYB-1 as a regulator of mitochondrial function that represses lysosomal prosaposin. The NFYB-1–prosaposin signalling axis coordinates lysosomal-to-mitochondria signalling via cardiolipin to enhance cellular mitochondrial function and longevity in C. elegans.

Rebecca George Tharyan
Andrea Annibal
Adam Antebi
Research18 May 2020
Nature Metabolism

Volume: 2, P: 387-396