Although the precipitating mechanisms of atrial fibrillation are not fully understood, atrial fibrosis is thought to set the stage for arrhythmia. Volker Rudolph et al. now show that the enzyme myeloperoxidase, released by inflammatory cells, is a key inducer of atrial fibrosis and arrhythmia in a mouse model of atrial fibrillation, and that myeloperoxidase levels are associated with atrial fibrillation in humans.
- Volker Rudolph
- René P Andrié
- Stephan Baldus
