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Showing 1–6 of 6 results
Advanced filters: Author: Birgit Niederreiter Clear advanced filters

  • Multinucleated giant cells (MGCs) are important in the pathogenesis of various diseases. Here, the authors demonstrate that extracellular presence of the amino acid arginine is required for MGC formation and metabolism, suggesting a translational impact for strategies utilizing systemic arginine depletion in MGC-mediated diseases.

    • Julia S. Brunner
    • Loan Vulliard
    • Gernot Schabbauer
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15

  • Kurt Redlich and his colleagues show that estrogen deficiency results in increased numbers of preosteoclast progenitor cells in the bones of mice. But they also find that lack of CCR2 in these future bone-resorbing cells prevents their maturation and thus protects the mice from osteoporosis, suggesting a future target for therapy in humans.

    • Nikolaus B Binder
    • Birgit Niederreiter
    • Kurt Redlich
    Research
    Nature Medicine
    Volume: 15, P: 417-424

  • Extensive records exist with which to assess the relationship between external climate forcings — such as changes in insolation — and climate variability for middle and high latitudes, but records from equatorial regions are relatively few, especially from regions experiencing the passage of the Intertropical Convergence Zone. A continuous and well-resolved climate-proxy record of hydrological variability during the past 25,000 years from equatorial East Africa is now presented and analysed.

    • Dirk Verschuren
    • Jaap S. Sinninghe Damsté
    • Norbert R. Nowaczyk
    Research
    Nature
    Volume: 462, P: 637-641

  • Fibroblast-like synoviocytes (FLS) are major contributors to joint inflammation in rheumatoid arthritis (RA). Here, the authors identified a previously unknown signaling circuit that contributes to tumor necrosis factor (TNF)-induced activation of FLS. The authors show that FOXO3 and its modulator PIK3IP1 are crucial for the TNF-driven interferon (IFN) response in RA-FLS.

    • Bernhard Brandstetter
    • Karolina Dalwigk
    • Thomas Karonitsch
    Research
    Laboratory Investigation
    Volume: 99, P: 648-658