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Structures and mechanism of the AUX/LAX transporters involved in auxin import

This study reveals the structural basis of auxin import by the AUX/LAX family. LAX3 binds auxin as well as herbicides via a proton-coupled mechanism, which offers insights into hormone recognition that is essential for lateral root growth.

Kien Lam Ung
Lukas Schulz
Bjørn Panyella Pedersen
ResearchOpen Access04 Aug 2025
Nature Plants

Volume: 11, P: 1670-1680
Author Correction: Structural determinants for activity of the antidepressant vortioxetine at human and rodent 5-HT₃ receptors

Uriel López-Sánchez
Lachlan Jake Munro
Anders S. Kristensen
Amendments and Corrections10 Jun 2024
Nature Structural & Molecular Biology

Volume: 31, P: 1145
Transport of phenoxyacetic acid herbicides by PIN-FORMED auxin transporters

PIN transporters are key players in distributing phenoxyacetic acid herbicides. Mutagenesis and cryo-EM structures elucidate substrate specificity and transport mechanisms, paving the way for improved synthetic auxin development and herbicide-resistant crops.

Lukas Schulz
Kien Lam Ung
Ulrich Z. Hammes
ResearchOpen Access22 Apr 2025
Nature Plants

Volume: 11, P: 1049-1059
Staphylococcus aureus functional amyloids catalyze degradation of β-lactam antibiotics

A number of mechanisms are known to mediate bacterial antibiotic resistance. Here, Arad et al show that amyloid fibrils produced by Staphylococcus aureus rapidly degrade common antibiotic molecules.

Elad Arad
Kasper B. Pedersen
Raz Jelinek
ResearchOpen Access11 Dec 2023
Nature Communications

Volume: 14, P: 1-15
Elevated concentrations cause upright alpha-synuclein conformation at lipid interfaces

The misfolding of alpha-synuclein is associated with neurodegenerative disorders such as Parkinson’s disease. The authors report a mechanism explaining why lipid membranes catalyze the formation of harmful aggregates at elevated concentrations.

Steven J. Roeters
Kris Strunge
Tobias Weidner
ResearchOpen Access18 Sept 2023
Nature Communications

Volume: 14, P: 1-12
Structural determinants for activity of the antidepressant vortioxetine at human and rodent 5-HT₃ receptors

The antidepressant vortioxetine affects rodent and human 5-HT₃ receptors differently. López-Sánchez et al. use a variety of methods, including structure determination of vortioxetine-bound human and mouse 5-HT₃ receptors, to reveal the basis of these differences.

Uriel López-Sánchez
Lachlan Jake Munro
Anders S. Kristensen
Research02 May 2024
Nature Structural & Molecular Biology

Volume: 31, P: 1232-1242
Structure and sucrose binding mechanism of the plant SUC1 sucrose transporter

The crystal structure of the Arabidopsis sucrose–proton symporter SUC1 is presented at 2.7 Å resolution. This allows the identification of a proton-driven symport process for SUC1 that may help in understanding how low-affinity transport can occur in enriched substrate environments.

Laust Bavnhøj
Jan Heiner Driller
Bjørn Panyella Pedersen
ResearchOpen Access15 May 2023
Nature Plants

Volume: 9, P: 938-950
Mutual adaptation of a membrane protein and its lipid bilayer during conformational changes

The detailed interactions of membrane proteins with their lipid environment are poorly understood. Sonntaget al. use low-resolution X-ray crystallographic data and molecular dynamics simulations to study the manner in which the sarcoendoplasmic reticulum Ca²⁺–ATPase adapts to different membrane environments.

Yonathan Sonntag
Maria Musgaard
Lea Thøgersen
Research10 May 2011
Nature Communications

Volume: 2, P: 1-7
Molecular mechanism of sugar transport in plants unveiled by structures of glucose/H⁺ symporter STP10

Sugar transport proteins (STPs) that are responsible for glucose uptake in plant cells play fundamental roles in plant growth, development and stress responses. High-resolution structures of Arabidopsis STP10 with glucose and protons bound are now resolved at two conformations, outward-occluded and inward-open, providing a general model for proton/glucose symport in STPs.

Laust Bavnhøj
Peter Aasted Paulsen
Bjørn Panyella Pedersen
Research23 Sept 2021
Nature Plants

Volume: 7, P: 1409-1419
A conserved leucine occupies the empty substrate site of LeuT in the Na⁺-free return state

Neurotransmitter:sodium symporters (NSS) perform Na⁺-dependent amino-acid uptake, but a full structural description of their function is lacking. Here the authors present a structure of the bacterial NSS LeuT in the outward-oriented empty state and show that a Leu residue occupies the empty substrate site and is essential for function.

Lina Malinauskaite
Saida Said
Poul Nissen
ResearchOpen Access25 May 2016
Nature Communications

Volume: 7, P: 1-11
Effect of palmitoylation on the dimer formation of the human dopamine transporter

Talia Zeppelin
Kasper B. Pedersen
Birgit Schiøtt
ResearchOpen Access18 Feb 2021
Scientific Reports

Volume: 11, P: 1-15
Dimer Interface of the Human Serotonin Transporter and Effect of the Membrane Composition

Xavier Periole
Talia Zeppelin
Birgit Schiøtt
ResearchOpen Access23 Mar 2018
Scientific Reports

Volume: 8, P: 1-15
Insight into the molecular mechanism behind PEG-mediated stabilization of biofluid lipases

Bianca Pérez
Andrea Coletta
Birgit Schiøtt
ResearchOpen Access16 Aug 2018
Scientific Reports

Volume: 8, P: 1-13

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Structures and mechanism of the AUX/LAX transporters involved in auxin import

Author Correction: Structural determinants for activity of the antidepressant vortioxetine at human and rodent 5-HT₃ receptors

Transport of phenoxyacetic acid herbicides by PIN-FORMED auxin transporters

Staphylococcus aureus functional amyloids catalyze degradation of β-lactam antibiotics

Elevated concentrations cause upright alpha-synuclein conformation at lipid interfaces

Structural determinants for activity of the antidepressant vortioxetine at human and rodent 5-HT₃ receptors

Structure and sucrose binding mechanism of the plant SUC1 sucrose transporter

Mutual adaptation of a membrane protein and its lipid bilayer during conformational changes

Molecular mechanism of sugar transport in plants unveiled by structures of glucose/H⁺ symporter STP10

A conserved leucine occupies the empty substrate site of LeuT in the Na⁺-free return state

Effect of palmitoylation on the dimer formation of the human dopamine transporter

Dimer Interface of the Human Serotonin Transporter and Effect of the Membrane Composition

Insight into the molecular mechanism behind PEG-mediated stabilization of biofluid lipases

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