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Showing 1–4 of 4 results
Advanced filters: Author: Birgitta Beatrix Clear advanced filters

  • The cryo-EM structure of the Saccharomyces cerevisiae 80S ribosome–Xrn1 nuclease complex reveals how the conserved core of Xrn1 allows binding at the mRNA exit channel of the ribosome, ensuring efficient degradation of mRNA after the final round of translation.

    • Petr Tesina
    • Elisabeth Heckel
    • Roland Beckmann
    Research
    Nature Structural & Molecular Biology
    Volume: 26, P: 275-280

  • A cryo-EM structure of the bacterial ribosome–SecYEG complex in a so-called Nanodisc allows for the molecular interpretation of the SecYEG complex in its natural lipid bilayer environment. Molecular dynamics simulations based on the structure reveal stable interactions between ribosomal RNA and the membrane that may contribute to the insertase activity of the protein-conducting channel.

    • Jens Frauenfeld
    • James Gumbart
    • Roland Beckmann
    Research
    Nature Structural & Molecular Biology
    Volume: 18, P: 614-621

  • Nascent secretory and membrane proteins are targeted to the Sec61 protein-conducting channel for translocation across or insertion into the endoplasmic reticulum membrane; here cryo-electron microscopy structures of eukaryotic ribosome–channel complexes show how this channel opens vertically during translocation of a secretory protein into the lumen of the endoplasmic reticulum and how it opens laterally during insertion of a transmembrane domain into the lipid bilayer.

    • Marko Gogala
    • Thomas Becker
    • Roland Beckmann
    Research
    Nature
    Volume: 506, P: 107-110