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Streptococcus pneumoniae epidemiology, pathogenesis and control

In this Review, Henriques-Normark and colleagues explore recent insights into Streptococcus pneumoniae epidemiology, clinical disease and pathogenesis, as well as new treatment and prevention approaches.

Ana Rita Narciso
Rebecca Dookie
Birgitta Henriques-Normark
Reviews06 Nov 2024
Nature Reviews Microbiology

Volume: 23, P: 256-271
The rise and fall of bacterial clones: Streptococcus pneumoniae

Clonal types of pathogenic bacteria differ in their ability to colonize, spread and cause disease in hosts. The evolution of bacterial clones and factors that contribute to the clonal spread of bacteria are discussed in this article, together with the relevance of bacterial clones to the progression of disease.

Birgitta Henriques-Normark
Christel Blomberg
Staffan Normark
Reviews01 Nov 2008
Nature Reviews Microbiology

Volume: 6, P: 827-837
Pneumolysin binds to the mannose receptor C type 1 (MRC-1) leading to anti-inflammatory responses and enhanced pneumococcal survival

A Streptococcus pneumoniae toxin, pneumolysin, binds to MRC-1 on phagocytes to dampen immune responses and promote infection.

Karthik Subramanian
Daniel R. Neill
Birgitta Henriques-Normark
Research12 Nov 2018
Nature Microbiology

Volume: 4, P: 62-70
The divisome but not the elongasome organizes capsule synthesis in Streptococcus pneumoniae

The bacterial cell envelope consists of multiple layers, the synthesis of which is coordinated through unclear mechanisms. Here, Nakamoto et al. reveal a mechanism linking the synthesis of capsular polysaccharides and cell wall peptidoglycan in pneumococci.

Rei Nakamoto
Sarp Bamyaci
Lok-To Sham
ResearchOpen Access01 Jun 2023
Nature Communications

Volume: 14, P: 1-13
Factor H binding proteins protect division septa on encapsulated Streptococcus pneumoniae against complement C3b deposition and amplification

Streptococcus pneumoniae evades the action of the complement system by expressing an immuno-protective polysaccharide capsule as well as Factor H-binding proteins. Here, Pathak et al. show that these two defence mechanisms are functionally and spatially coordinated on the bacterial cell surface.

Anuj Pathak
Jan Bergstrand
Birgitta Henriques-Normark
ResearchOpen Access23 Aug 2018
Nature Communications

Volume: 9, P: 1-16
How neutrophils recognize bacteria and move toward infection

The finding that CD38 mediates a sustained calcium signal inside neutrophils, which directs their movement toward lung tissue infected with pneumococcus bacteria suggests a new mechanism by which the immune system prevents the spread of bacterial infection. (pages 1209–1216)

Staffan Normark
Birgitta Henriques Normark
Mathias Hornef
News & Views01 Nov 2001
Nature Medicine

Volume: 7, P: 1182-1184
Hosting for the cruel and the inconsequential

Responses to group A streptococcal infection vary from slight discomfort to death. Now it seems that human susceptibility can depend on polymorphisms in genes encoding human leukocyte antigen class II (pages 1398–1404).

Birgitta Henriques Normark
Staffan Normark
News & Views01 Dec 2002
Nature Medicine

Volume: 8, P: 1349-1350
Staphylococcal protein A inflames the lungs

Staphylococcal pneumonia is associated with a huge influx of inflammatory cells into the lungs. A major trigger for this event is now revealed. Protein A, a bacterial surface protein, binds the receptor for TNFα, a prominent activator of the innate immune system (pages 842–848).

Birgitta Henriques Normark
Staffan Normark
Anna Norrby-Teglund
News & Views01 Aug 2004
Nature Medicine

Volume: 10, P: 780-781
Enterobacteria impair host p53 tumor suppressor activity through mRNA destabilization

Marie-Stéphanie Aschtgen
Konstantinos Fragkoulis
Sylvain Peuget
ResearchOpen Access23 Feb 2022
Oncogene

Volume: 41, P: 2173-2186
Gradient acoustic focusing of sub-micron particles for separation of bacteria from blood lysate

David Van Assche
Elisabeth Reithuber
Per Augustsson
ResearchOpen Access28 Feb 2020
Scientific Reports

Volume: 10, P: 1-13
The BR domain of PsrP interacts with extracellular DNA to promote bacterial aggregation; structural insights into pneumococcal biofilm formation

Tim Schulte
Cecilia Mikaelsson
Adnane Achour
ResearchOpen Access01 Sept 2016
Scientific Reports

Volume: 6, P: 1-11

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Streptococcus pneumoniae epidemiology, pathogenesis and control

The rise and fall of bacterial clones: Streptococcus pneumoniae

Pneumolysin binds to the mannose receptor C type 1 (MRC-1) leading to anti-inflammatory responses and enhanced pneumococcal survival

The divisome but not the elongasome organizes capsule synthesis in Streptococcus pneumoniae

Factor H binding proteins protect division septa on encapsulated Streptococcus pneumoniae against complement C3b deposition and amplification

How neutrophils recognize bacteria and move toward infection

Hosting for the cruel and the inconsequential

Staphylococcal protein A inflames the lungs

Enterobacteria impair host p53 tumor suppressor activity through mRNA destabilization

Gradient acoustic focusing of sub-micron particles for separation of bacteria from blood lysate

The BR domain of PsrP interacts with extracellular DNA to promote bacterial aggregation; structural insights into pneumococcal biofilm formation

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