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Showing 1–4 of 4 results
Advanced filters: Author: Bluma J Lesch Clear advanced filters

  • Repeat-rich sequences play a role in 3D genome architecture in higher eukaryotes; however, this remains unexplored in brain cells. Here, the authors show that upregulation of endogenous retroviral (ERV) sequences is linked to changes in the 3D structure in the brain, which is also observed by comparison of mouse strains with recent retrotransposon expansion.

    • Sandhya Chandrasekaran
    • Sergio Espeso-Gil
    • Schahram Akbarian
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16

  • David Page and colleagues examine genes with bivalent chromatin modifications in male germ cells from five mammalian species and chicken. They find that the set of bivalently marked genes shared by all species represent evolutionarily ancient morphogenesis regulators, whereas genes showing lineage-specific bivalent marks act downstream of these core regulators.

    • Bluma J Lesch
    • Sherman J Silber
    • David C Page
    Research
    Nature Genetics
    Volume: 48, P: 888-894

  • Recent advances in genetic technologies have progressed the understanding of the biological pathways mediating the control of germ cell development. In this Review the genes and strategies involved inDrosophila melanogaster, Caenorhabditis elegansand mouse germline development are compared and contrasted.

    • Bluma J. Lesch
    • David C. Page
    Reviews
    Nature Reviews Genetics
    Volume: 13, P: 781-794