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Showing 1–4 of 4 results

Advanced filters: Author: Bo-Syong Pan Clear advanced filters

ALDH4A1 functions as an active component of the MPC complex maintaining mitochondrial pyruvate import for TCA cycle entry and tumour suppression

Hsu, Wang, Manne et al. identify ALDH4A1 as a component of the mitochondrial pyruvate carrier complex, which plays a non-canonical role in regulating pyruvate homeostasis in mitochondria, TCA cycle entry and tumour suppression.

Che-Chia Hsu
Chi-Yun Wang
Hui-Kuan Lin
Research12 May 2025
Nature Cell Biology

Volume: 27, P: 847-862
H3 ubiquitination by NEDD4 regulates H3 acetylation and tumorigenesis

Histone modifications play important roles in gene transcription and cancer. Here the authors establish a role for the E3 ubiquitin ligase NEDD4 in modifying in a glucose-dependent manner the histone H3, thus regulating the expression of genes involved in tumorigenesis.

Xian Zhang
Binkui Li
Hui-Kuan Lin
ResearchOpen Access16 Mar 2017
Nature Communications

Volume: 8, P: 1-15
Cordycepin induced MA-10 mouse Leydig tumor cell apoptosis by regulating p38 MAPKs and PI3K/AKT signaling pathways

Bo-Syong Pan
Yang-Kao Wang
Bu-Miin Huang
ResearchOpen Access25 Aug 2015
Scientific Reports

Volume: 5, P: 1-17
Abnormal gametogenesis induced by p53 deficiency promotes tumor progression and drug resistance

Chunfang Liu
Zhen Cai
Hui-Kuan Lin
ResearchOpen Access02 Oct 2018
Cell Discovery

Volume: 4, P: 1-16