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Showing 1–6 of 6 results
Advanced filters: Author: Bob Jacques Clear advanced filters

  • Meta-analysis of genome-wide association studies on Alzheimer’s disease and related dementias identifies new loci and enables generation of a new genetic risk score associated with the risk of future Alzheimer’s disease and dementia.

    • Céline Bellenguez
    • Fahri Küçükali
    • Jean-Charles Lambert
    ResearchOpen Access
    Nature Genetics
    Volume: 54, P: 412-436

  • Current emissions scenarios include pathways that overshoot the temperature goals set out in the Paris Agreement and rely on future net negative emissions. Limiting overshoot would require near-term investment but would result in longer-term economic benefit.

    • Keywan Riahi
    • Christoph Bertram
    • Behnam Zakeri
    Research
    Nature Climate Change
    Volume: 11, P: 1063-1069

  • Mitigation pathways allowing for temperature overshoot often ignore the related climate and macroeconomic impacts. Net-zero pathways with limited overshoot could reduce low-probability high-consequence risks and economic loss.

    • Laurent Drouet
    • Valentina Bosetti
    • Massimo Tavoni
    Research
    Nature Climate Change
    Volume: 11, P: 1070-1076

    • John Harris
    • John Sulston
    Reviews
    Nature Reviews Genetics
    Volume: 5, P: 796-800

  • Roger Milne and colleagues conduct a genome-wide association study for estrogen receptor (ER)-negative breast cancer combined with BRCA1 mutation carriers in a large cohort. They identify ten new risk variants and find high genetic correlation between breast cancer risk for BRCA1 mutation carriers and risk of ER-negative breast cancer in the general population.

    • Roger L Milne
    • Karoline B Kuchenbaecker
    • Jacques Simard
    Research
    Nature Genetics
    Volume: 49, P: 1767-1778