Because scar formation is regulated by genetic and epigenetic influences, the authors tested the hypothesis that abnormalities in DNA hydroxymethylation in hypertrophic scar formation. They found that 5-hydroxymethylcytosine loss in scar fibroblasts is associated with depletion of TET3 (a DNA methylation enzyme) and increased expression of focal adhesion kinase; and that these effects are partially diminished by ascorbic acid.
- Yukun Liu
- Shuyun Xu
- Christine G. Lian
