The transcription factor PU.1 recruits c-Jun as a co-activator to promoters without AP-1 binding sites, and mice with point mutations in PU.1 that disrupts the interaction between PU1 and c-Jun have defects in PU.1 dependent blood lineages, including macrophages and B cells.
- Xinhui Zhao
- Boris Bartholdy
- Daniel G. Tenen
