Nature Search

C-JUN overexpressing CAR-T cells in acute myeloid leukemia: preclinical characterization and phase I trial

Chimeric Antigen Receptor (CAR)-T cells show suboptimal efficacy in Acute Myeloid Leukaemia (AML). Here, the authors show that overexpression of C-JUN improves CAR-T cells efficacy in preclinical models for AML and report preliminary results of a pilot phase I clinical trial.

Shiyu Zuo
Chuo Li
Xiaoming Feng
ResearchOpen Access22 Jul 2024
Nature Communications

Volume: 15, P: 1-20
A proof of concept study of ¹⁸F-FDG PET/CT patient-level radiomics identify refractory/relapsed diffuse large B-cell lymphoma

Caozhe Cui
Jianbo Cao
Zhifang Wu
ResearchOpen Access30 Sept 2025
Scientific Reports

Volume: 15, P: 1-11
Embedding high-resolution touch across robotic hands enables adaptive human-like grasping

Developing robotic hands that can adapt to real-world dynamics remains a substantial challenge. The authors present an AI system that mimics human-like grasping using full-hand tactile sensing and a sensory–motor feedback mechanism.

Zihang Zhao
Wanlin Li
Song-Chun Zhu
ResearchOpen Access09 Jun 2025
Nature Machine Intelligence

Volume: 7, P: 889-900
Metabotropic glutamate receptor 4-mediated glutamatergic signaling reshapes the tumor microenvironment by regulating dendritic cell maturation

Metabotropic glutamate receptor 4 (mGluR4) is a neurotransmitter receptor receiving signals from the central nervous system. Here authors show a non-neuronal, tumour-autonomous role for mGluR4 in suppressing dendritic cell maturation and function in multiple murine cancers, and that inhibiting mGluR4 chemically by Forskolin or via genomic deletion enhances the immune response against tumours.

Xiaoman Ju
Eva Maria Putz
Juming Yan
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-21
CD22 CAR T-cell therapy in refractory or relapsed B acute lymphoblastic leukemia

Jing Pan
Qing Niu
Chunrong Tong
ResearchOpen Access20 May 2019
Leukemia

Volume: 33, P: 2854-2866
Serum Uric Acid Is Associated with Erectile Dysfunction: A Population-Based Cross-Sectional Study in Chinese Men

Fengbin Gao
Boren Jiang
Zhoujun Shen
ResearchOpen Access18 May 2017
Scientific Reports

Volume: 7, P: 1-7
Predicting the risk of avian influenza A H7N9 infection in live-poultry markets across Asia

An avian influenza virus of the H7N9 type, associated with live-poultry markets, has caused two human epidemics in China. Here, the authors develop a statistical model that predicts the risk of H7N9 infection in live-poultry markets across Asia, as a tool for disease surveillance and control.

Marius Gilbert
Nick Golding
Hongjie Yu
ResearchOpen Access17 Jun 2014
Nature Communications

Volume: 5, P: 1-7
Allogeneic stem cell transplantation combined with conditioning regimen including donor-derived CAR-T cells for refractory/relapsed B-cell lymphoma

Fan Yang
Hui Shi
Kai Hu
CorrespondenceOpen Access22 Dec 2022
Bone Marrow Transplantation

Volume: 58, P: 440-442
A novel full-human CD22-CAR T cell therapy with potent activity against CD22^low B-ALL

Yue Tan
Haodong Cai
Jing Pan
CorrespondenceOpen Access10 Apr 2021
Blood Cancer Journal

Volume: 11, P: 1-6
Potent and long-lasting humoral and cellular immunity against varicella zoster virus induced by mRNA-LNP vaccine

Anannya Bhattacharya
Lonzaric Jan
Antu K. Dey
ResearchOpen Access04 Apr 2024
npj Vaccines

Volume: 9, P: 1-14
Clinical implications of residual normal plasma cells within bone marrow across various disease stages in multiple myeloma

Wenqiang Yan
Lihui Shi
Gang An
Research02 Aug 2024
Leukemia

Volume: 38, P: 2235-2245
Warming deferentially altered multidimensional soil legacy induced by past land use history

Weiling Dong
Alin Song
Fenliang Fan
ResearchOpen Access24 Jan 2018
Scientific Reports

Volume: 8, P: 1-10
Evaluation of macrophage-specific promoters using lentiviral delivery in mice

M C Levin
U Lidberg
I Gjertsson
Research01 Dec 2011
Gene Therapy

Volume: 19, P: 1041-1047
Interaction of liming and long-term fertilization increased crop yield and phosphorus use efficiency (PUE) through mediating exchangeable cations in acidic soil under wheat–maize cropping system

Muhammad Qaswar
Li Dongchu
Wang Boren
ResearchOpen Access13 Nov 2020
Scientific Reports

Volume: 10, P: 1-12
Cadmium exposure and its association with serum uric acid and hyperuricemia

Honglin Sun
Ningjian Wang
Yingli Lu
ResearchOpen Access03 Apr 2017
Scientific Reports

Volume: 7, P: 1-8
Author Correction: Potent and long-lasting humoral and cellular immunity against varicella zoster virus induced by mRNA-LNP vaccine

Anannya Bhattacharya
Lonzaric Jan
Antu K. Dey
Amendments and CorrectionsOpen Access18 Nov 2024
npj Vaccines

Volume: 9, P: 1
Apoptosis-induced mitochondrial dysfunction causes cytoplasmic lipid droplet formation

J Boren
K M Brindle
ResearchOpen Access30 Mar 2012
Cell Death & Differentiation

Volume: 19, P: 1561-1570

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