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Showing 1–2 of 2 results
Advanced filters: Author: Boris Rudolfs Clear advanced filters

  • Determining structures of small, protein-free RNAs by cryo-EM has been challenging. Here, the authors use a group II intron scaffold to achieve high-resolution RNA structures, visualize ligand-induced changes, and enable de novo modeling of non-coding RNAs.

    • Daniel B. Haack
    • Boris Rudolfs
    • Navtej Toor
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17

  • The formation of the 2′–5′ lariat bond during branching is the critical first step in RNA splicing. A structure of a group II intron reveals a conserved base triple responsible for positioning the adenosine nucleophile to attack the 5′ splice site.

    • Daniel B. Haack
    • Boris Rudolfs
    • Navtej Toor
    Research
    Nature Structural & Molecular Biology
    Volume: 31, P: 179-189