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Showing 1–17 of 17 results
Advanced filters: Author: Boris Striepen Clear advanced filters

  • The little-studied parasite Cryptosporidium is a major threat to infants. Boris Striepen calls on microbiologists and funders to give it more attention.

    • Boris Striepen
    Comments & Opinion
    Nature
    Volume: 503, P: 189-191

  • Cryptosporidium is an important cause of diarrhoeal disease in young children but until now it has been difficult to study; here, the parasite is genetically modified, paving the way for in-depth investigation and the development of effective treatments.

    • Sumiti Vinayak
    • Mattie C. Pawlowic
    • Boris Striepen
    Research
    Nature
    Volume: 523, P: 477-480

  • Parasite infections such as malaria threaten the lives of millions of people around the globe. New genetic tools have been developed to evaluate parasite proteins as targets for urgently needed drug and vaccine development.

    • Boris Striepen
    News & Views
    Nature Methods
    Volume: 4, P: 999-1000

  • Apicomplexan parasites have a complex life cycle that relies on highly regulated development inside host cells. Here, Francia and Striepen give an overview of apicomplexan cell cycle progression and cell division and the ways in which these processes are spatially and temporally guided by the centrosome in these pathogenic parasites.

    • Maria E. Francia
    • Boris Striepen
    Reviews
    Nature Reviews Microbiology
    Volume: 12, P: 125-136

  • A molecular machine used by the malaria parasite to export its protein armoury into the host cell has at last been identified, providing researchers with a potentially invaluable therapeutic target.

    • Sarah B. Reiff
    • Boris Striepen
    News & Views
    Nature
    Volume: 459, P: 918-919

  • Infection with Cryptosporidium parvum is a leading cause of severe diarrhoeal disease and childhood mortality worldwide. Using tools they recently developed to genetically engineer Cryptosporidium, the authors define life cycle stage-specific markers and generate reporter parasites, making life cycle progression and parasite sex tractable.

    • Jayesh Tandel
    • Elizabeth D. English
    • Boris Striepen
    ResearchOpen Access
    Nature Microbiology
    Volume: 4, P: 2226-2236

  • The establishment of a drug-discovery screening pipeline for cryptosporidiosis, and identification of pyrazolopyridines as selective ATP-competitive inhibitors of the Cryptosporidium lipid kinase PI(4)K.

    • Ujjini H. Manjunatha
    • Sumiti Vinayak
    • Thierry T. Diagana
    Research
    Nature
    Volume: 546, P: 376-380

  • The authors identified a series of cytoskeletal proteins involved in the discharge of invasion-related organelles in Toxoplasma gondii. They successfully delineated their functions through the utilization of expansion and cryo-electron microscopy.

    • Nicolas Dos Santos Pacheco
    • Albert Tell i Puig
    • Dominique Soldati-Favre
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • The rhoptry is an apical secretory organelle of apicomplexan parasites that is essential for host cell invasion. Here, Mageswaran et al. provide in situ ultrastructures of rhoptries from two pathogens, revealing a conserved architecture including luminal filaments and a distinct docking mechanism.

    • Shrawan Kumar Mageswaran
    • Amandine Guérin
    • Yi-Wei Chang
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • Apicomplexan parasites utilize a unique actomyosin system to mediate motility and host cell invasion. Here, the authors apply cryo-ET to Cryptosporidium parvum and Toxoplasma gondii to visualize the F-actin architecture in the native cellular context.

    • Matthew Martinez
    • Shrawan Kumar Mageswaran
    • Yi-Wei Chang
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16

  • Plasmodium and Toxoplasma parasites rely on rhoptry exocytosis for invasion, but the underlying mechanism is not known. Here, Suarez et al. characterize rhoptry apical surface proteins (RASP) that localize to the rhoptry cap and bind charged lipids, and are essential for rhoptry secretion and invasion.

    • Catherine Suarez
    • Gaëlle Lentini
    • Maryse Lebrun
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14

  • Cryptosporidium are protozoan parasites that infect intestinal epithelial cells and can cause severe diarrhoeal disease, particularly in malnourished children. This Review summarizes the immune mechanisms that protect against this parasitic infection, highlighting the innate mechanisms that detect Cryptosporidium at the intestinal epithelium and the adaptive immune mechanisms that mediate resistance.

    • Ryan D. Pardy
    • Bethan A. Wallbank
    • Christopher A. Hunter
    Reviews
    Nature Reviews Immunology
    Volume: 24, P: 142-155