Nature Search

Autism-associated SNPs in the clock genes npas2, per1 and the homeobox gene en2 alter DNA sequences that show characteristics of microRNA genes.

Brad Nicholas
Michael Owen
Thomas Caspari
ResearchOpen Access07 Oct 2008
Nature Precedings

P: 1
Author Correction: Large-scale network analysis of the cerebrospinal fluid proteome identifies molecular signatures of frontotemporal lobar degeneration

Rowan Saloner
Adam M. Staffaroni
Kaitlin B. Casaletto
Amendments and CorrectionsOpen Access07 Jul 2025
Nature Aging

Volume: 5, P: 1372
Proteogenomic characterization of invasive breast tumors in young women

Praveen-Kumar Raj-Kumar
Jianfang Liu
Hai Hu
ResearchOpen Access18 Aug 2025
npj Breast Cancer

Volume: 11, P: 1-19
Evaluation of FluSight influenza forecasting in the 2021–22 and 2022–23 seasons with a new target laboratory-confirmed influenza hospitalizations

This manuscript evaluates forecasts of laboratory-confirmed influenza hospital admissions, a new target for influenza forecasting in the United States. Across two influenza seasons, the FluSight ensemble is robust compared to submitted models.

Sarabeth M. Mathis
Alexander E. Webber
Rebecca K. Borchering
ResearchOpen Access26 Jul 2024
Nature Communications

Volume: 15, P: 1-13
A manufacturable platform for photonic quantum computing

A manufacturable platform for quantum computing with photons is introduced and a set of monolithically integrated silicon-photonics-based modules is benchmarked, demonstrating dual-rail photonic qubits with performance close to thresholds required for operation.

Koen Alexander
Avishai Benyamini
Xinran Zhou
ResearchOpen Access26 Feb 2025
Nature

Volume: 641, P: 876-883
Large-scale network analysis of the cerebrospinal fluid proteome identifies molecular signatures of frontotemporal lobar degeneration

Saloner et al. used large-scale cerebrospinal fluid proteomics to uncover molecular signatures in frontotemporal dementia, revealing RNA splicing and synaptic protein candidate markers for genetic and sporadic disease progression.

Rowan Saloner
Adam M. Staffaroni
Kaitlin B. Casaletto
ResearchOpen Access16 May 2025
Nature Aging

Volume: 5, P: 1143-1158
The chromatin landscape of healthy and injured cell types in the human kidney

Comprehensive integration of gene expression with epigenetic features is needed to understand the transition of kidney cells from health to injury. Here, the authors integrate dual single nucleus RNA expression and chromatin accessibility, DNA methylation, and histone modifications to decipher the chromatin landscape of the kidney in reference and adaptive injury cell states, identifying a transcription factor network of ELF3, KLF6, and KLF10 which regulates adaptive repair and maladaptive failed repair.

Debora L. Gisch
Michelle Brennan
Michael T. Eadon
ResearchOpen Access10 Jan 2024
Nature Communications

Volume: 15, P: 1-21
Author Correction: Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia

Joseph A. Fraietta
Simon F. Lacey
J. Joseph Melenhorst
Amendments and Corrections05 Feb 2021
Nature Medicine

Volume: 27, P: 561
The high optical brightness of the BlueWalker 3 satellite

We report the outcome of an international optical observation campaign of a prototype constellation satellite, AST SpaceMobile’s BlueWalker 3, which features a 64.3 m² phased-array antenna and a launch vehicle adaptor.

Sangeetha Nandakumar
Siegfried Eggl
Mario Soto
ResearchOpen Access02 Oct 2023
Nature

Volume: 623, P: 938-941
Multiomic analysis of homologous recombination-deficient end-stage high-grade serous ovarian cancer

Multiple samples collected at autopsy from women with homologous recombination-deficient high-grade serous ovarian cancer highlight substantial inter- and intratumoral heterogeneity. A plethora of resistance mechanisms were identified within and between patients.

Nikki L. Burdett
Madelynne O. Willis
Elizabeth L. Christie
Research27 Feb 2023
Nature Genetics

Volume: 55, P: 437-450
The genomic and immune landscape of long-term survivors of high-grade serous ovarian cancer

A genomic and transcriptomic analysis identifies molecular features associated with long-term survival in ovarian cancer. Exceptional survival was heterogeneous across the cohort, suggesting that it is likely the function of multiple cell-intrinsic and microenvironmental factors working in combination.

Dale W. Garsed
Ahwan Pandey
David D. L. Bowtell
Research01 Dec 2022
Nature Genetics

Volume: 54, P: 1853-1864
Whole-genome sequencing identifies common-to-rare variants associated with human blood metabolites

Amalio Telenti, Craig Venter and colleagues report common, low-frequency and rare variants associated with blood metabolite levels using whole-genome sequencing and comprehensive metabolite profiling in 1,960 individuals. They identify 246 metabolites whose levels are associated with genetic variation at 101 loci.

Tao Long
Michael Hicks
Amalio Telenti
Research06 Mar 2017
Nature Genetics

Volume: 49, P: 568-578
Stroke among cancer patients

The risk of fatal stroke is increased in children, adolescent, and young (<40 years) cancer patients after diagnosis. Here, the authors report a retrospective, population-based study and show that the risk of stroke among cancer patients is twice that of the general population and rises with longer follow up time.

Nicholas G. Zaorsky
Ying Zhang
Brad E. Zacharia
ResearchOpen Access15 Nov 2019
Nature Communications

Volume: 10, P: 1-8
Regulation of autism-relevant behaviors by cerebellar–prefrontal cortical circuits

Kelly et al. describe two cerebellum–thalamus–mPFC pathways in mice that regulate social and repetitive behavior. PC activation in Rcrus1 and posterior vermis improved social and reduced repetitive behaviors, respectively, in PC-Tsc1 mutant mice.

Elyza Kelly
Fantao Meng
Peter T. Tsai
Research13 Jul 2020
Nature Neuroscience

Volume: 23, P: 1102-1110
A nutrient-limited screen unmasks rifabutin hyperactivity for extensively drug-resistant Acinetobacter baumannii

In this Article, using a nutrient-limited, media-based compound screening, the authors discover that the old antibiotic rifabutin is highly active against extensively drug-resistant Acinetobacter baumannii.

Brian Luna
Vincent Trebosc
Brad Spellberg
Research08 Jun 2020
Nature Microbiology

Volume: 5, P: 1134-1143
Giant aeolian dune size determined by the average depth of the atmospheric boundary layer

This paper shows that the growth of aeolian giant dunes, ascribed to the non-linear interaction between small-scale superimposed dunes, is limited by the confinement of the flow over the average depth of the atmospheric boundary layer. The findings explain the mean spacing of aeolian giant dunes ranging from 300 metres in coastal deserts to 3.5 kilometres.

Bruno Andreotti
Antoine Fourrière
Philippe Claudin
Research26 Feb 2009
Nature

Volume: 457, P: 1120-1123
Selective small-molecule inhibition of an RNA structural element

A novel drug, ribocil, is shown to mimic the binding of a natural ligand to a bacterial riboflavin riboswitch (a non-coding stretch of messenger RNA whose structure is affected by a ligand—usually one related to the function of the protein encoded by the messenger RNA) to cause inhibition of bacterial growth; the ability to target an RNA structural element with a synthetic small molecule may expand our view of the target space susceptible to therapeutic intervention.

John A. Howe
Hao Wang
Terry Roemer
Research30 Sept 2015
Nature

Volume: 526, P: 672-677
Author Correction: T cell and antibody responses induced by a single dose of ChAdOx1 nCoV-19 (AZD1222) vaccine in a phase 1/2 clinical trial

Katie J. Ewer
Jordan R. Barrett
Elizabeth Stafford
Amendments and Corrections21 May 2021
Nature Medicine

Volume: 27, P: 1116
Phase 1/2 trial of SARS-CoV-2 vaccine ChAdOx1 nCoV-19 with a booster dose induces multifunctional antibody responses

Two doses of the coronavirus disease 2019 vaccine ChAdOx1 nCoV-19 boost antibody responses and functions in phase 1/2 trial participants.

Jordan R. Barrett
Sandra Belij-Rammerstorfer
Dalila Zizi
Research17 Dec 2020
Nature Medicine

Volume: 27, P: 279-288
Comprehensive genomic characterization defines human glioblastoma genes and core pathways

With a comprehensive analysis of sequencing data, DNA copy number, gene expression and DNA methylation in a large number of human glioblastomas, The Cancer Genome Atlas project initiative provides a broad overview of the genes and pathways that are altered in this cancer type.

Roger McLendon
Allan Friedman
Elizabeth Thomson
Research04 Sept 2008
Nature

Volume: 455, P: 1061-1068
Rapid, high-throughput library preparation for next-generation sequencing

Haiying Grunenwald
Brad Baas
Fraz Syed
Advertorial01 Aug 2010
Nature Methods

Volume: 7, P: iii-iv
T cell and antibody responses induced by a single dose of ChAdOx1 nCoV-19 (AZD1222) vaccine in a phase 1/2 clinical trial

A single dose of the ChAdOx1 nCoV-19 vaccine elicits antibodies and cytokine-producing T cells that might help control or prevent SARS-CoV-2 infection.

Katie J. Ewer
Jordan R. Barrett
Elizabeth Stafford
Research17 Dec 2020
Nature Medicine

Volume: 27, P: 270-278
Author Correction: Phase 1/2 trial of SARS-CoV-2 vaccine ChAdOx1 nCoV-19 with a booster dose induces multifunctional antibody responses

Jordan R. Barrett
Sandra Belij-Rammerstorfer
Dalila Zizi
Amendments and Corrections06 May 2021
Nature Medicine

Volume: 27, P: 1113
Estimating the risk of brain metastasis for patients newly diagnosed with cancer

Miccio et al. utilize the US National Cancer Database (NCDB) to develop models to estimate the risk of brain metastasis for newly-diagnosed cancers. They provide nomograms and a web tool for risk estimation across multiple cancer types.

Joseph A. Miccio
Zizhong Tian
Nicholas G. Zaorsky
ResearchOpen Access22 Feb 2024
Communications Medicine

Volume: 4, P: 1-12
Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia

An IL-6/STAT3 signature and memory CD8 T cell subset in preinfusion chimeric antigen receptor–expressing T cells associate with response in patients with high-risk chronic lymphocytic leukemia.

Joseph A. Fraietta
Simon F. Lacey
J. Joseph Melenhorst
Research30 Apr 2018
Nature Medicine

Volume: 24, P: 563-571
Functional prediction of response to therapy prior to therapeutic intervention is associated with improved survival in patients with high-grade glioma

Aubrey Ledford
Analiz Rodriguez
Teresa M. DesRochers
ResearchOpen Access29 Aug 2024
Scientific Reports

Volume: 14, P: 1-16
Proteogenomic analysis of enriched HGSOC tumor epithelium identifies prognostic signatures and therapeutic vulnerabilities

Nicholas W. Bateman
Tamara Abulez
G. Larry Maxwell
ResearchOpen Access13 Mar 2024
npj Precision Oncology

Volume: 8, P: 1-17
AI is a viable alternative to high throughput screening: a 318-target study

Izhar Wallach
Denzil Bernard
Abraham Heifets
ResearchOpen Access02 Apr 2024
Scientific Reports

Volume: 14, P: 1-16
AusTraits, a curated plant trait database for the Australian flora

Daniel Falster
Rachael Gallagher
Kasia Ziemińska
ResearchOpen Access30 Sept 2021
Scientific Data

Volume: 8, P: 1-20
Immunization with a Trypanosoma cruzi cyclophilin-19 deletion mutant protects against acute Chagas disease in mice

Bijay Kumar Jha
Sanjay Varikuti
Bradford S. McGwire
ResearchOpen Access25 Apr 2023
npj Vaccines

Volume: 8, P: 1-15
Twenty-first-century projections of shoreline change along inlet-interrupted coastlines

Janaka Bamunawala
Roshanka Ranasinghe
Ad van der Spek
ResearchOpen Access07 Jul 2021
Scientific Reports

Volume: 11, P: 1-14
Blind testing of shoreline evolution models

Jennifer Montaño
Giovanni Coco
Kilian Vos
ResearchOpen Access07 Feb 2020
Scientific Reports

Volume: 10, P: 1-10
Author Correction: Proteogenomic analysis of enriched HGSOC tumor epithelium identifies prognostic signatures and therapeutic vulnerabilities

Nicholas W. Bateman
Tamara Abulez
G. Larry Maxwell
Amendments and CorrectionsOpen Access06 May 2024
npj Precision Oncology

Volume: 8, P: 1
Untargeted metabolomics reveals N, N, N-trimethyl-L-alanyl-L-proline betaine (TMAP) as a novel biomarker of kidney function

Thomas J. Velenosi
Benjamin K. A. Thomson
Bradley L. Urquhart
ResearchOpen Access02 May 2019
Scientific Reports

Volume: 9, P: 1-13
A user-friendly tool for cloud-based whole slide image segmentation with examples from renal histopathology

Lutnick et al. develop a cloud-based deep learning tool for whole slide image segmentation. The authors provide several examples of its application in renal pathology, for segmenting glomeruli, interstitial fibrosis and other features of interest.

Brendon Lutnick
David Manthey
Angela Victoria-Castro
ResearchOpen Access19 Aug 2022
Communications Medicine

Volume: 2, P: 1-15
Author Correction: AI is a viable alternative to high throughput screening: a 318-target study

Izhar Wallach
Denzil Bernard
Ellie Giles
Amendments and CorrectionsOpen Access16 Sept 2024
Scientific Reports

Volume: 14, P: 1-2

Search

Autism-associated SNPs in the clock genes npas2, per1 and the homeobox gene en2 alter DNA sequences that show characteristics of microRNA genes.

Author Correction: Large-scale network analysis of the cerebrospinal fluid proteome identifies molecular signatures of frontotemporal lobar degeneration

Proteogenomic characterization of invasive breast tumors in young women

Evaluation of FluSight influenza forecasting in the 2021–22 and 2022–23 seasons with a new target laboratory-confirmed influenza hospitalizations

A manufacturable platform for photonic quantum computing

Large-scale network analysis of the cerebrospinal fluid proteome identifies molecular signatures of frontotemporal lobar degeneration

The chromatin landscape of healthy and injured cell types in the human kidney

Author Correction: Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia

The high optical brightness of the BlueWalker 3 satellite

Multiomic analysis of homologous recombination-deficient end-stage high-grade serous ovarian cancer

The genomic and immune landscape of long-term survivors of high-grade serous ovarian cancer

Whole-genome sequencing identifies common-to-rare variants associated with human blood metabolites

Stroke among cancer patients

Regulation of autism-relevant behaviors by cerebellar–prefrontal cortical circuits

A nutrient-limited screen unmasks rifabutin hyperactivity for extensively drug-resistant Acinetobacter baumannii

Giant aeolian dune size determined by the average depth of the atmospheric boundary layer

Selective small-molecule inhibition of an RNA structural element

Author Correction: T cell and antibody responses induced by a single dose of ChAdOx1 nCoV-19 (AZD1222) vaccine in a phase 1/2 clinical trial

Phase 1/2 trial of SARS-CoV-2 vaccine ChAdOx1 nCoV-19 with a booster dose induces multifunctional antibody responses

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

Rapid, high-throughput library preparation for next-generation sequencing

T cell and antibody responses induced by a single dose of ChAdOx1 nCoV-19 (AZD1222) vaccine in a phase 1/2 clinical trial

Author Correction: Phase 1/2 trial of SARS-CoV-2 vaccine ChAdOx1 nCoV-19 with a booster dose induces multifunctional antibody responses

Estimating the risk of brain metastasis for patients newly diagnosed with cancer

Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia

Functional prediction of response to therapy prior to therapeutic intervention is associated with improved survival in patients with high-grade glioma

Proteogenomic analysis of enriched HGSOC tumor epithelium identifies prognostic signatures and therapeutic vulnerabilities

AI is a viable alternative to high throughput screening: a 318-target study

AusTraits, a curated plant trait database for the Australian flora

Immunization with a Trypanosoma cruzi cyclophilin-19 deletion mutant protects against acute Chagas disease in mice

Twenty-first-century projections of shoreline change along inlet-interrupted coastlines

Blind testing of shoreline evolution models

Author Correction: Proteogenomic analysis of enriched HGSOC tumor epithelium identifies prognostic signatures and therapeutic vulnerabilities

Untargeted metabolomics reveals N, N, N-trimethyl-L-alanyl-L-proline betaine (TMAP) as a novel biomarker of kidney function

A user-friendly tool for cloud-based whole slide image segmentation with examples from renal histopathology

Author Correction: AI is a viable alternative to high throughput screening: a 318-target study

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