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Advanced filters: Author: Brad Windle Clear advanced filters

  • The mechanisms of how gain-of-function (GOF) mutant p53 drives carcinogenesis are unclear. Here, the authors show that a GOF mutant p53 requires its transactivation capability to induce mouse lung tumors and this is dependent on PLK3 phosphorylation of GOF mutant p53.

    • Catherine A. Vaughan
    • Shilpa Singh
    • Sumitra Deb
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-19