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Mitigation of off-target toxicity in CRISPR-Cas9 screens for essential non-coding elements

Off-target effects in CRISPR screens for essential regulatory elements have not been systematically evaluated. Here the authors find Cas9 nuclease, CRISPRi/a each have distinct off-target effects, and that these can be accurately identified and removed using the GuideScan sgRNA specificity score.

Josh Tycko
Michael Wainberg
Michael C. Bassik
ResearchOpen Access06 Sept 2019
Nature Communications

Volume: 10, P: 1-14
Identification of phagocytosis regulators using magnetic genome-wide CRISPR screens

Eight genome-wide CRISPR screens identify genes required for substrate-specific phagocytosis. The study highlights roles for NHLRC2 in filopodia formation, very-long-chain fatty acids in substrate-specific phagocytosis and TM2D3 in uptake of amyloid-β aggregates.

Michael S. Haney
Christopher J. Bohlen
Michael C. Bassik
Research05 Nov 2018
Nature Genetics

Volume: 50, P: 1716-1727
Phagolysosome resolution requires contacts with the endoplasmic reticulum and phosphatidylinositol-4-phosphate signalling

Levin-Konigsberg et al. show that resorption of the phagolysosome after degradation of its contents requires transfer of PI4P and tethering to the ER, both mediated by oxysterol-binding protein-related protein 1L (ORP1L).

Roni Levin-Konigsberg
Fernando Montaño-Rendón
Sergio Grinstein
Research30 Sept 2019
Nature Cell Biology

Volume: 21, P: 1234-1247

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