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Showing 1–5 of 5 results
Advanced filters: Author: Bram Prevo Clear advanced filters

  • Cytoplasmic dynein 2 drives retrograde intraflagellar transport but little is known about its dynamics. Here the authors use fluorescence microscopy to track labelled dynein 2 inC. elegansat the single-molecule level and report diffusion at the ciliary base, and pausing and directional switches along the cilium.

    • Jona Mijalkovic
    • Bram Prevo
    • Erwin J. G. Peterman
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-9

  • Mitotic chromosomes recruit multiple microtubule-directed activities to ensure their faithful segregation. Using an approach where only one major activity is present, the authors reveal sufficiency of kinetochore dynein for chromosome biorientation.

    • Bram Prevo
    • Dhanya K. Cheerambathur
    • Arshad Desai
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13

  • In this Review, the authors summarize DNA packaging in bacteriophage, bacteria and eukaryotic cells. They describe the difficulties each system faces when packaging its DNA, outline the molecular motor components involved, and provide insights from new studies that reveal how DNA organization is achieved.

    • Bram Prevo
    • William C. Earnshaw
    Reviews
    Nature Reviews Genetics
    Volume: 25, P: 785-802

  • Sensory cilia assembly has been proposed to occur through the kinesin-2-driven delivery of precursors to the axoneme tip by intraflagellar transport (IFT). Microscopy analysis and mathematical modelling provide evidence that tubulin subunits are transported to their sites of incorporation into microtubules at axonemal tips by IFT.

    • Limin Hao
    • Melanie Thein
    • Jonathan M. Scholey
    Research
    Nature Cell Biology
    Volume: 13, P: 790-798