The authors report that the chloride channel CLC-3 colocalizes with the vesicular GABA transporter VGAT in the CA1 region of the hippocampus, where it affected Cl−-induced acidification of synaptic vesicles. Clcn3−/− animals showed a decrement in inhibitory transmission, suggesting a decrease in neurotransmitter loading of synaptic vesicles.
- Vladimir Riazanski
- Ludmila V Deriy
- Deborah J Nelson
