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Showing 1–8 of 8 results
Advanced filters: Author: Brent L Nannenga Clear advanced filters

  • Although members of the Hsp70-DnaK family of heat shock proteins are involved in nearly all aspects of cell physiology, some mechanistic details of their mode of action remain obscure. A new substrate helps establish DnaK as an unfoldase that requires as little as five ATP molecules to drive the refolding of one protein.

    • François Baneyx
    • Brent L Nannenga
    News & Views
    Nature Chemical Biology
    Volume: 6, P: 880-881

  • High-resolution, three-dimensional protein structures can be solved using MicroED, an electron diffraction method that uses three-dimensional microcrystals. An improved MicroED data collection approach described here increases data quality and resolution and extends its broad applicability.

    • Brent L Nannenga
    • Dan Shi
    • Tamir Gonen
    Research
    Nature Methods
    Volume: 11, P: 927-930

  • Cryo-EM reveals an asymmetric bacterial photosynthetic supercomplex built upon a homodimeric reaction center core. The structure provides mechanistic insights into light excitation transfer and a possible evolutionary transition intermediate of photosynthetic machinery.

    • Ryan Puskar
    • Chloe Du Truong
    • Po-Lin Chiu
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-12

  • MicroED is a cryo-EM technique for collecting electron diffraction data from microcrystals and nanocrystals. This protocol from Gonen and colleagues describes how to prepare the protein crystal samples, how to set up the electron microscope for MicroED, and diffraction data collection.

    • Dan Shi
    • Brent L Nannenga
    • Tamir Gonen
    Protocols
    Nature Protocols
    Volume: 11, P: 895-904

  • A short segment of α-synuclein called NACore (residues 68–78) is responsible for the formation of amyloid aggregates responsible for cytotoxicity in Parkinson disease; here the nanocrystal structure of this invisible-to-optical-microscopy segment is determined using micro-electron diffraction, offering insight into its function and simultaneously demonstrating the first use of micro-electron diffraction to solve a previously unknown protein structure.

    • Jose A. Rodriguez
    • Magdalena I. Ivanova
    • David S. Eisenberg
    Research
    Nature
    Volume: 525, P: 486-490

  • This paper reviews the cryo-EM technique of microcrystal electron diffraction (MicroED), providing a broad overview of the technique, the unique structures determined, and the opportunities for future development.

    • Brent L. Nannenga
    • Tamir Gonen
    Reviews
    Nature Methods
    Volume: 16, P: 369-379