Inhibition of Bcl-2 and Bcl-xL by ABT-737 is known to enhance tumor cell death. Here the authors find that it is actually protective against neuronal death in an animal model of ischemia via blockade of Bcl-xL–induced mitochondrial channel activity. These findings point to Bcl-xL as a potential therapeutic target.
- Dimitry Ofengeim
- Ying-bei Chen
- Elizabeth A Jonas
