Nature Search

Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci

Tom Karlsen and colleagues report a genome-wide association study for primary sclerosing cholangitis, a chronic bile duct disease. They identify susceptibility loci at MST1 and near BCL2L11.

Espen Melum
Andre Franke
Tom H Karlsen
Research12 Dec 2010
Nature Genetics

Volume: 43, P: 17-19
Variants at IRF5-TNPO3, 17q12-21 and MMEL1 are associated with primary biliary cirrhosis

Katherine Siminovitch and colleagues report replication and fine-mapping studies for primary biliary cirrhosis. They identify three loci newly associated with susceptibility to this autoimmune liver disease.

Gideon M Hirschfield
Xiangdong Liu
Katherine A Siminovitch
Research18 Jul 2010
Nature Genetics

Volume: 42, P: 655-657
A scalable workflow to characterize the human exposome

Humans are exposed to millions of chemicals but mass spectrometry (MS)-based targeted biomonitoring assays are usually limited to a few hundred known hazards. Here, the authors develop a workflow for MS-based untargeted exposome profiling of known and unidentified environmental chemicals.

Xin Hu
Douglas I. Walker
Dean P. Jones
ResearchOpen Access22 Sept 2021
Nature Communications

Volume: 12, P: 1-12
International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways

Primary biliary cirrhosis is an autoimmune liver disease with poor therapeutic options. Here Cordell et al. a perform meta-analysis of European genome-wide association studies identifying six novel risk loci and a number of potential therapeutic pathways.

Heather J. Cordell
Younghun Han
Katherine A. Siminovitch
ResearchOpen Access22 Sept 2015
Nature Communications

Volume: 6, P: 1-11
Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease

Konstantinos Lazaridis, Carl Anderson and colleagues report results of a genome-wide association study of primary sclerosing cholangitis (PSC). They identify four new susceptibility loci for PSC and quantify the correlation of common genetic variation shared between PSC and inflammatory bowel diseases.

Sun-Gou Ji
Brian D Juran
Carl A Anderson
Research19 Dec 2016
Nature Genetics

Volume: 49, P: 269-273
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci

David Ellinghaus and colleagues report a combined association analysis of five chronic inflammatory diseases. They identify 27 new associations and highlight disease-specific association patterns at shared susceptibility loci.

David Ellinghaus
Luke Jostins
Andre Franke
Research14 Mar 2016
Nature Genetics

Volume: 48, P: 510-518
Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis

Tom Karlsen and colleagues report an association study for primary sclerosing cholangitis (PSC), a severe liver disease, using the Immunochip array. They identify nine loci newly associated with PSC and examine pleiotropy with other autoimmune disorders.

Jimmy Z Liu
Johannes Roksund Hov
Tom H Karlsen
Research21 Apr 2013
Nature Genetics

Volume: 45, P: 670-675
Single-cell mass cytometry on peripheral blood identifies immune cell subsets associated with primary biliary cholangitis

Jin Sung Jang
Brian D. Juran
Konstantinos N. Lazaridis
ResearchOpen Access28 Jul 2020
Scientific Reports

Volume: 10, P: 1-13
Hypermethylation of the spleen tyrosine kinase promoter in T-lineage acute lymphoblastic leukemia

Patricia A Goodman
Nicole Burkhardt
Faith M Uckun
Research25 Apr 2003
Oncogene

Volume: 22, P: 2504-2514

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Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci

Variants at IRF5-TNPO3, 17q12-21 and MMEL1 are associated with primary biliary cirrhosis

A scalable workflow to characterize the human exposome

International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways

Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease

Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci

Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis

Single-cell mass cytometry on peripheral blood identifies immune cell subsets associated with primary biliary cholangitis

Hypermethylation of the spleen tyrosine kinase promoter in T-lineage acute lymphoblastic leukemia

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