Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–6 of 6 results
Advanced filters: Author: Brian D Stadinski Clear advanced filters

  • Lo and colleagues report that double-positive thymocytes from neonates express less Zap70 and show reduced Ca2⁺/NFAT signaling compared to double-positive thymocytes from older thymi. This diminished Ca2⁺ signaling alters negative selection for self-reactive TCRs, resulting in a cell-intrinsic temporal window for regulatory T versus conventional T cell development in the thymus.

    • Brian D. Stadinski
    • Elizabeth A. Mills
    • Wan-Lin Lo
    ResearchOpen Access
    Nature Immunology
    P: 1-14

  • Treg cells are essential for self-tolerance. Huseby and colleagues identify multiple de facto Treg cell self-peptides and show that Treg cells are exported from the thymus within a defined postnatal developmental window that is controlled by their increased negative selection.

    • Brian D. Stadinski
    • Sydney J. Blevins
    • Eric S. Huseby
    Research
    Nature Immunology
    Volume: 20, P: 1046-1058

  • The identity of self antigens targeted in various autoimmune diseases is often unknown. Haskins and colleagues identify a chromagranin A epitope whose presentation by I-Ag7 involves an unusual peptide-binding mode.

    • Brian D Stadinski
    • Thomas Delong
    • Kathryn Haskins
    Research
    Nature Immunology
    Volume: 11, P: 225-231

  • Type 1 diabetes is associated with homozygous expression of specific major histocompatibility complex class II beta chain polymorphisms. Here the authors show that the disease-protective effect of major histocompatibility complex class II heterozygosity is conferred by non-cognate thymocyte negative selection.

    • Brian D. Stadinski
    • Sarah B. Cleveland
    • Eric S. Huseby
    Research
    Nature Immunology
    Volume: 24, P: 652-663

  • Through analyses of β-chain variable regions in self-reactive T cell antigen receptors, Huseby and colleagues show that an index based on the interfacial hydrophobicity of amino acids at positions 6 and 7 of the CDR3β segment distinguishes self-reactive T cell antigen receptors.

    • Brian D Stadinski
    • Karthik Shekhar
    • Eric S Huseby
    Research
    Nature Immunology
    Volume: 17, P: 946-955

  • Regulatory T cells (Treg cells) have essential roles in maintaining immunohomeostasis. Palmer and colleagues identify two distinct subsets of Treg cells with differing degrees of self-reactivity and regulatory function.

    • Lena Wyss
    • Brian D Stadinski
    • Ed Palmer
    Research
    Nature Immunology
    Volume: 17, P: 1093-1101