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Showing 1–3 of 3 results
Advanced filters: Author: Brian E. Cathers Clear advanced filters

  • This paper reports the identification of a new cereblon-modulating agent, CC-885, which targets the translation termination factor GSPT1 and demonstrates anti-tumour activity in patient-derived tumour cells; the crystal structure of the cereblon–DDB1–GSPT1–CC-885 complex reveals a common motif for cereblon-substrate recruitment.

    • Mary E. Matyskiela
    • Gang Lu
    • Philip P. Chamberlain
    Research
    Nature
    Volume: 535, P: 252-257

  • Lenalidomide, a derivative of thalidomide, is an effective drug for myelodysplastic syndrome; lenalidomide binds the CRL4CRBN E3 ubiquitin ligase and promotes degradation of casein kinase 1a, on which the malignant cells rely for survival.

    • Jan Krönke
    • Emma C. Fink
    • Benjamin L. Ebert
    Research
    Nature
    Volume: 523, P: 183-188