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A TMPRSS2 inhibitor acts as a pan-SARS-CoV-2 prophylactic and therapeutic

A small-molecule inhibitor of TMPRSS2 is effective against SARS-CoV-2 variants of concern in human lung cells and in donor-derived colonoids, and also shows prophylactic and therapeutic benefits in a mouse model of COVID-19.

Tirosh Shapira
I. Abrrey Monreal
François Jean
ResearchOpen Access28 Mar 2022
Nature

Volume: 605, P: 340-348
Multivalent viral particles elicit safe and efficient immunoprotection against Nipah Hendra and Ebola viruses

Duncan G. Ithinji
David W. Buchholz
Hector C. Aguilar
ResearchOpen Access17 Dec 2022
npj Vaccines

Volume: 7, P: 1-14

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A﻿ TMPRSS2 inhibitor acts as a pan-SARS-CoV-2 prophylactic and therapeutic

Multivalent viral particles elicit safe and efficient immunoprotection against Nipah Hendra and Ebola viruses

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A TMPRSS2 inhibitor acts as a pan-SARS-CoV-2 prophylactic and therapeutic