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Showing 1–7 of 7 results
Advanced filters: Author: Brian P Vickery Clear advanced filters

  • Sequencing of over 600 genes in a large collection of lung adenocarcinoma samples provides an overview of somatic mutations and signalling pathways altered in cancer genes in this tumour type.

    • Li Ding
    • Gad Getz
    • Richard K. Wilson
    Research
    Nature
    Volume: 455, P: 1069-1075

  • Cryo-electron microscopy structures of the bacterial O-antigen ligase WaaL, combined with genetics, biochemistry and molecular dynamics simulations, provide insight into the mechanism by which WaaL catalyses the biosynthesis of lipopolysaccharide.

    • Khuram U. Ashraf
    • Rie Nygaard
    • Filippo Mancia
    Research
    Nature
    Volume: 604, P: 371-376

  • Bacterial cell shape is dependent on the formation of the extracellular sugar polymer called peptidoglycan. Here the authors describe RodA-PBP2, the enzymatic core of the elongasome, which is the complex responsible peptidoglycan synthesis, and utilize an integrated approach to investigate the mechanism of peptidoglycan biosynthesis.

    • Rie Nygaard
    • Chris L. B. Graham
    • Filippo Mancia
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15

  • Whole-genome analysis of oestrogen-receptor-positive tumours in patients treated with aromatase inhibitors show that distinct phenotypes are associated with specific patterns of somatic mutations; however, most recurrent mutations are relatively infrequent so prospective clinical trials will require comprehensive sequencing and large study populations.

    • Matthew J. Ellis
    • Li Ding
    • Elaine R. Mardis
    ResearchOpen Access
    Nature
    Volume: 486, P: 353-360

  • Marc Rothenberg, John Harley and colleagues present the results of a genome-wide association study of eosinophilic esophagitis. They discover an association with variants near CAPN14 and show that CAPN14 is expressed specifically in the esophagus and is upregulated in esophageal biopsies of individuals with active disease.

    • Leah C Kottyan
    • Benjamin P Davis
    • Marc E Rothenberg
    Research
    Nature Genetics
    Volume: 46, P: 895-900

  • With a comprehensive analysis of sequencing data, DNA copy number, gene expression and DNA methylation in a large number of human glioblastomas, The Cancer Genome Atlas project initiative provides a broad overview of the genes and pathways that are altered in this cancer type.

    • Roger McLendon
    • Allan Friedman
    • Elizabeth Thomson
    Research
    Nature
    Volume: 455, P: 1061-1068