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Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor gene in mice

Lutz Hein
Gregory S. Barsh
Brian K. Kobilka
Research26 Oct 1995
Nature

Volume: 377, P: 744-747
A pairwise distance distribution correction (DDC) algorithm to eliminate blinking-caused artifacts in SMLM

Distance distribution correction (DDC) eliminates repeat localizations caused by fluorophore blinking without the need for calibrations. Use of DDC yields accurate and quantifiable single-molecule localization microscopy data.

Christopher H. Bohrer
Xinxing Yang
Jie Xiao
Research31 May 2021
Nature Methods

Volume: 18, P: 669-677
Genetically encoded biosensors for visualizing live-cell biochemical activity at super-resolution

New fluorescent biosensors enable the first super-resolution imaging of enzyme activity in live cells via fluorescence fluctuation increase by contact (FLINC).

Gary C H Mo
Brian Ross
Jin Zhang
Research13 Mar 2017
Nature Methods

Volume: 14, P: 427-434
An ultrasensitive biosensor for high-resolution kinase activity imaging in awake mice

A fluorescence-based sensor of PKA activity has increased brightness, dynamic range and signal-to-noise ratio over related sensors and is useful for visualizing kinase activity in HeLa cells, primary neurons and the cortex of awake mice.

Jin-Fan Zhang
Bian Liu
Jin Zhang
Research28 Sept 2020
Nature Chemical Biology

Volume: 17, P: 39-46
Single-fluorophore biosensors for sensitive and multiplexed detection of signalling activities

Mehta et al. create single-fluorophore kinase activity sensors for PKA, PKC and ERK in different colours, and demonstrate that they enable multiplex imaging of a combination of signalling activities in cell lines and primary rat neurons.

Sohum Mehta
Yong Zhang
Jin Zhang
Research24 Sept 2018
Nature Cell Biology

Volume: 20, P: 1215-1225