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Showing 1–5 of 5 results
Advanced filters: Author: Brianna Lowey Clear advanced filters

  • Gut microbiota play a critical role in drug metabolism. Now, by exploring the human gut microbial metabolism of G-protein-coupled receptor (GPCR)-targeting drugs, uncommon pathways and biotransformations are elucidated, revealing how the activity of the metabolized drugs against target GPCRs is modulated.

    • Qihao Wu
    • Deguang Song
    • Jason M. Crawford
    Research
    Nature Chemistry
    Volume: 17, P: 808-821

  • Structures of prokaryotic homologues of STING permit the reconstruction of the evolutionary trajectory of its incorporation into metazoan innate immunity, and reveal a role for the conserved cGAS–STING pathway in prokaryotic defence against bacteriophages.

    • Benjamin R. Morehouse
    • Apurva A. Govande
    • Philip J. Kranzusch
    Research
    Nature
    Volume: 586, P: 429-433

  • A bacterial family of cGAS/DncV-like nucleotidyltransferases synthesizes a diverse range of cyclic dinucleotide and trinucleotide compounds that are likely to modulate the interaction of both pathogens and commensal microbiota with their animal and plant hosts.

    • Aaron T. Whiteley
    • James B. Eaglesham
    • Philip J. Kranzusch
    Research
    Nature
    Volume: 567, P: 194-199

  • Using genome-wide miRNA mimic and hairpin inhibitor screens, Li et al. identify 31 miRNAs that either inhibit or promote hepatitis C virus (HCV) replication at different steps of the viral life cycle. Furthermore, human liver biopsies show that HCV down-regulates identified miRNAs with antiviral function.

    • Qisheng Li
    • Brianna Lowey
    • T. Jake Liang
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-16