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Showing 1–4 of 4 results
Advanced filters: Author: Brianna R. Ramirez Clear advanced filters

  • Microglia clearance activity in adult brain is regulated epigenetically and region-specifically to match neuronal attrition rates. Uncoupling this activity from neural apoptosis leads to aberrant microglia activation & neurodegenerative-like changes.

    • Pinar Ayata
    • Ana Badimon
    • Anne Schaefer
    Research
    Nature Neuroscience
    Volume: 21, P: 1049-1060

  • Identification and characterization, using a comprehensive embryonic phenotyping pipeline, of 410 lethal alleles during the generation of the first 1,751 of 5,000 unique gene knockouts produced by the International Mouse Phenotyping Consortium.

    • Mary E. Dickinson
    • Ann M. Flenniken
    • Stephen A. Murray
    Research
    Nature
    Volume: 537, P: 508-514

  • Schahram Akbarian and colleagues report that mutation of the gene encoding the SETDB1 (KMT1E) histone methyltransferase in mouse neurons leads to dissolution of chromosome conformations and a topologically associated domain at the clustered protocadherin locus. They show that SETDB1 prevents excess CTCF binding and is important for maintaining developmentally important higher-order chromatin organization.

    • Yan Jiang
    • Yong-Hwee Eddie Loh
    • Schahram Akbarian
    Research
    Nature Genetics
    Volume: 49, P: 1239-1250