Nature Search

Correction: Corrigendum: Brain feminization requires active repression of masculinization via DNA methylation

Bridget M Nugent
Christopher L Wright
Margaret M McCarthy
Amendments and Corrections25 May 2017
Nature Neuroscience

Volume: 20, P: 896
Reproductive tract extracellular vesicles are sufficient to transmit intergenerational stress and program neurodevelopment

Evidence for sperm small noncoding RNA-mediated intergenerational transmission implies communication from responsive somatic cells to sperm. Here, authors show that epididymal cells alter extracellular vesicle cargo after stress exposure, to impact offspring neurodevelopment and stress reactivity.

Jennifer C. Chan
Christopher P. Morgan
Tracy L. Bale
ResearchOpen Access20 Mar 2020
Nature Communications

Volume: 11, P: 1-13
Brain feminization requires active repression of masculinization via DNA methylation

Hormone-induced brain masculinization occurs during a perinatal sensitive period but endures into adulthood. Researchers explored DNA methylation as a candidate mechanism. Methylation is higher in female brain and suppresses masculinization genes, which are liberated by hormone-induced reductions in DNMT activity in males. Pharmacological inhibition of DNMTs reduces methylation, masculinizes female brain and behavior and reopens the sensitive period.

Bridget M Nugent
Christopher L Wright
Margaret M McCarthy
Research30 Mar 2015
Nature Neuroscience

Volume: 18, P: 690-697
Placental H3K27me3 establishes female resilience to prenatal insults

Sex differences in placental O-linked N-acetylglucosamine transferase (OGT) activity mediate the effects of prenatal stress on neurodevelopmental programming. Here authors provide evidence that OGT confers variation in vulnerability to prenatal insults by establishing sex-specific trophoblast gene expression via regulation of H3K27me3.

Bridget M. Nugent
Carly M. O’Donnell
Tracy L. Bale
ResearchOpen Access02 Jul 2018
Nature Communications

Volume: 9, P: 1-10
Ethanol blocks a novel form of iLTD, but not iLTP of inhibitory inputs to VTA GABA neurons

Teresa M. Nufer
Bridget J. Wu
Jeffrey G. Edwards
Research10 Mar 2023
Neuropsychopharmacology

Volume: 48, P: 1396-1408
Neuroimmunology and neuroepigenetics in the establishment of sex differences in the brain

Sex differences in behaviour and disease vulnerability are mirrored by the cellular and molecular sexual dimorphism of the brain. McCarthy and colleagues review findings that have highlighted the roles of inflammation and epigenetics in sex-specific brain differentiation and function.

Margaret M. McCarthy
Bridget M. Nugent
Kathryn M. Lenz
Reviews22 Jun 2017
Nature Reviews Neuroscience

Volume: 18, P: 471-484
Developmental transcriptomic patterns can be altered by transgenic overexpression of Uty

Kylie D. Rock
Lillian M. Folts
Tracy L. Bale
ResearchOpen Access30 Nov 2023
Scientific Reports

Volume: 13, P: 1-14

Search

Filter By:

Correction: Corrigendum: Brain feminization requires active repression of masculinization via DNA methylation

Reproductive tract extracellular vesicles are sufficient to transmit intergenerational stress and program neurodevelopment

Brain feminization requires active repression of masculinization via DNA methylation

Placental H3K27me3 establishes female resilience to prenatal insults

Ethanol blocks a novel form of iLTD, but not iLTP of inhibitory inputs to VTA GABA neurons

Neuroimmunology and neuroepigenetics in the establishment of sex differences in the brain

Developmental transcriptomic patterns can be altered by transgenic overexpression of Uty

Search

Quick links