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Showing 1–2 of 2 results
Advanced filters: Author: Bridget M Trevillian Clear advanced filters

  • Computational design enables the generation of a chimeric construct of the RAS exchange factor SOS that is specifically activated by a small molecule. The expression of this construct in different cell types reveals distinct phosphorylation kinetics.

    • John C Rose
    • Po-Ssu Huang
    • Dustin J Maly
    Research
    Nature Chemical Biology
    Volume: 13, P: 119-126

  • A rapidly inducible, autoinhibited SpCas9 and quantitative assessment of double-strand cleavage and indel formation allow insights into Cas9 kinetics in cell lines.

    • John C Rose
    • Jason J Stephany
    • Douglas M Fowler
    Research
    Nature Methods
    Volume: 14, P: 891-896