Previous models of γ-tubulin ring complex (γTuRC) assembly implied that γ-tubulin complex proteins (GCPs) 4–6 serve as a scaffold for arranging multiple γ-tubulin small complexes (γTuSCs) into large γTuRCs. The crystal structure of human GCP4 represents a prototype for all GCPs and can be precisely positioned within γTuSC, providing a new framework for understanding γTuRC formation.
- Valérie Guillet
- Martine Knibiehler
- Lionel Mourey
