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Showing 1–3 of 3 results
Advanced filters: Author: Bristol Denlinger Clear advanced filters

  • Gram-negative bacterial infections can often cause inflammation and pain. Meseguer et al. show that the inflammation and pain result from the direct activation of nociceptor TRPA1 channels by lipopolysaccharide, a major component of the outer membrane of Gram-negative bacteria.

    • Victor Meseguer
    • Yeranddy A. Alpizar
    • Félix Viana
    ResearchOpen Access
    Nature Communications
    Volume: 5, P: 1-14

  • Zhang, McNaughton and colleagues show that inflammatory stimuli promote a direct association between the heterotrimeric G-protein subunit Gαq and the temperature-sensitive ion channel TRPM8. This interaction inhibits TRPM8 channel activity, providing a mechanism by which inflammation produces aberrant sensations of temperature changes.

    • Xuming Zhang
    • Stephanie Mak
    • Peter A. McNaughton
    Research
    Nature Cell Biology
    Volume: 14, P: 851-858