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Advanced filters: Author: Brittany L. Overlee Clear advanced filters

Endosomal PI(3)P regulation by the COMMD/CCDC22/CCDC93 (CCC) complex controls membrane protein recycling

Recycling of proteins that have entered the endosome is essential to homeostasis. The COMMD/CCDC22/CCDC93 (CCC) complex is regulator of recycling but the molecular mechanisms are unclear. Here, the authors report that the CCC complex regulates endosomal recycling by maintaining PI3P levels on endosomal membranes.

Amika Singla
Alina Fedoseienko
Daniel D. Billadeau
ResearchOpen Access19 Sept 2019
Nature Communications

Volume: 10, P: 1-17
Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling

McNally et al. identify the retriever complex as required for endosomal cargo recycling. Retriever binds SNX17, the CCC and WASH complexes to govern cell surface expression of integrins, receptors and transporters.

Kerrie E. McNally
Rebecca Faulkner
Peter J. Cullen
Research11 Sept 2017
Nature Cell Biology

Volume: 19, P: 1214-1225
Peripheral blood mononuclear cell phenotype and function are maintained after overnight shipping of whole blood

Renee K. Johnson
Brittany L. Overlee
Charles L. Howe
ResearchOpen Access19 Nov 2022
Scientific Reports

Volume: 12, P: 1-14

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