Nature Search

A pathologist–AI collaboration framework for enhancing diagnostic accuracies and efficiencies

A digital pathology–artificial intelligence framework that leverages active learning and clinician-in-the-loop real-time feedback improves performance in diagnostic tasks.

Zhi Huang
Eric Yang
James Zou
Research19 Jun 2024
Nature Biomedical Engineering

Volume: 9, P: 455-470
Origins and impact of extrachromosomal DNA

A study examines the diversity of extrachromosomal DNA elements in cancer, and provides details on the frequency and origin of extrachromosomal DNA and its role in the development of different types of cancer.

Chris Bailey
Oriol Pich
Charles Swanton
ResearchOpen Access06 Nov 2024
Nature

Volume: 635, P: 193-200
Mapping spatial organization and genetic cell-state regulators to target immune evasion in ovarian cancer

Here the authors provide a resource for ovarian cancer combining spatial transcriptomics, genomics, CRISPR Perturb-seq screens and in silico methods to focus on T cells and natural killer cells in the tumor and their role in immune evasion.

Christine Yiwen Yeh
Karmen Aguirre
Livnat Jerby
ResearchOpen Access23 Aug 2024
Nature Immunology

Volume: 25, P: 1943-1958
DNA methylation-based classification of sinonasal tumors

Sinonasal tumour diagnosis can be complicated by the heterogeneity of disease and classification systems. Here, the authors use machine learning to classify sinonasal undifferentiated carcinomas into 4 molecular classe with differences in differentiation state and clinical outcome.

Philipp Jurmeister
Stefanie Glöß
David Capper
ResearchOpen Access28 Nov 2022
Nature Communications

Volume: 13, P: 1-14
Mutational spectrum of Barrett’s stem cells suggests paths to initiation of a precancerous lesion

Barrett’s oesophagus is a precancerous intestinal metaplasia that can progress to oesophageal adenocarcinoma. In this study, the authors isolate and characterize human Barrett’s stem cells and identify a specific genomic pedigree that supports the potential role of these cells as precursors of oesophageal adenocarcinoma.

Yusuke Yamamoto
Xia Wang
Wa Xian
ResearchOpen Access19 Jan 2016
Nature Communications

Volume: 7, P: 1-10
Transcript-specific enrichment enables profiling of rare cell states via single-cell RNA sequencing

Programmable Enrichment via RNA FlowFISH by sequencing (PERFF-seq) isolates rare cells based on RNA marker transcripts for single-cell RNA sequencing profiling of complex tissues, with applicability to a broad variety of samples and cell types.

Tsion Abay
Robert R. Stickels
Caleb A. Lareau
Research08 Jan 2025
Nature Genetics

Volume: 57, P: 451-460
Cloning and variation of ground state intestinal stem cells

Novel technology to rapidly clone patient-specific, ‘ground state’ stem cells of columnar epithelia reveals their proliferative potential, remarkably precise and origin-dependent lineage commitment as well as genomic stability, despite extensive culturing, thereby skirting limitations associated with pluripotent stem cells.

Xia Wang
Yusuke Yamamoto
Wa Xian
Research03 Jun 2015
Nature

Volume: 522, P: 173-178
Targeted next-generation sequencing in the detection of mismatch repair deficiency in endometrial cancers

Fei Dong
Danielle C. Costigan
Brooke E. Howitt
Research11 Sept 2018
Modern Pathology

Volume: 32, P: 252-257
Targeted genomic profiling reveals recurrent KRAS mutations and gain of chromosome 1q in mesonephric carcinomas of the female genital tract

Jelena Mirkovic
Lynette M Sholl
Brooke E Howitt
Research04 Sept 2015
Modern Pathology

Volume: 28, P: 1504-1514
Prospective molecular classification of endometrial carcinomas: institutional implementation, practice, and clinical experience

Kelly A. Devereaux
Julianna J. Weiel
Brooke E. Howitt
Research06 Nov 2021
Modern Pathology

Volume: 35, P: 688-696
Ovarian cancer

Ovarian cancer is a global health problem that is generally diagnosed at a late stage and has no effective screening strategy. This Primer by Matulonis et al. discusses the risk factors, genetics, diagnosis and management of ovarian cancer.

Ursula A. Matulonis
Anil K. Sood
Beth Y. Karlan
Reviews25 Aug 2016
Nature Reviews Disease Primers

Volume: 2, P: 1-22
Atypical uterine polyps show morphologic and molecular overlap with mullerian adenosarcoma but follow a benign clinical course

David B. Chapel
Brooke E. Howitt
Marisa R. Nucci
Research21 Oct 2021
Modern Pathology

Volume: 35, P: 106-116
SMARCA4-deficient undifferentiated uterine sarcoma (malignant rhabdoid tumor of the uterus): a clinicopathologic entity distinct from undifferentiated carcinoma

David L. Kolin
Fei Dong
Brooke E. Howitt
Research26 Apr 2018
Modern Pathology

Volume: 31, P: 1442-1456
Morphologic correlates of molecular alterations in extrauterine Müllerian carcinomas

Lauren L Ritterhouse
Jonathan A Nowak
Brooke E Howitt
Research06 May 2016
Modern Pathology

Volume: 29, P: 893-903
Pattern-based classification of invasive endocervical adenocarcinoma, depth of invasion measurement and distinction from adenocarcinoma in situ: interobserver variation among gynecologic pathologists

Carlos Parra-Herran
Monica Taljaard
Brooke E Howitt
Research13 May 2016
Modern Pathology

Volume: 29, P: 879-892
Differentiated exophytic vulvar intraepithelial lesions are genetically distinct from keratinizing squamous cell carcinomas and contain mutations in PIK3CA

Jaclyn C Watkins
Brooke E Howitt
Christopher P Crum
Research11 Nov 2016
Modern Pathology

Volume: 30, P: 448-458
HPV-independent, p53-wild-type vulvar intraepithelial neoplasia: a review of nomenclature and the journey to characterize verruciform and acanthotic precursor lesions of the vulva

Carlos Parra-Herran
Marisa R. Nucci
Jaclyn C. Watkins
Reviews18 Apr 2022
Modern Pathology

Volume: 35, P: 1317-1326

Search

A pathologist–AI collaboration framework for enhancing diagnostic accuracies and efficiencies

Origins and impact of extrachromosomal DNA

Mapping spatial organization and genetic cell-state regulators to target immune evasion in ovarian cancer

DNA methylation-based classification of sinonasal tumors

Mutational spectrum of Barrett’s stem cells suggests paths to initiation of a precancerous lesion

Transcript-specific enrichment enables profiling of rare cell states via single-cell RNA sequencing

Cloning and variation of ground state intestinal stem cells

Targeted next-generation sequencing in the detection of mismatch repair deficiency in endometrial cancers

Targeted genomic profiling reveals recurrent KRAS mutations and gain of chromosome 1q in mesonephric carcinomas of the female genital tract

Prospective molecular classification of endometrial carcinomas: institutional implementation, practice, and clinical experience

Ovarian cancer

Atypical uterine polyps show morphologic and molecular overlap with mullerian adenosarcoma but follow a benign clinical course

SMARCA4-deficient undifferentiated uterine sarcoma (malignant rhabdoid tumor of the uterus): a clinicopathologic entity distinct from undifferentiated carcinoma

Morphologic correlates of molecular alterations in extrauterine Müllerian carcinomas

Pattern-based classification of invasive endocervical adenocarcinoma, depth of invasion measurement and distinction from adenocarcinoma in situ: interobserver variation among gynecologic pathologists

Differentiated exophytic vulvar intraepithelial lesions are genetically distinct from keratinizing squamous cell carcinomas and contain mutations in PIK3CA

HPV-independent, p53-wild-type vulvar intraepithelial neoplasia: a review of nomenclature and the journey to characterize verruciform and acanthotic precursor lesions of the vulva

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