Nature Search

Genome-wide association study identifies novel breast cancer susceptibility loci

Previous work has identified several genes where mutations lead to breast cancer, but other genetic and environmental factors must still be accounted for. A large study of genetic association with breast cancer points to four novel genes and many more genetic markers that should be pursued for their link to cancer susceptibility.

Douglas F. Easton
Karen A. Pooley
Bruce A. J. Ponder
Research28 Jun 2007
Nature

Volume: 447, P: 1087-1093
Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants

Paul R Burton
David G Clayton
Matthew A Brown
Research21 Oct 2007
Nature Genetics

Volume: 39, P: 1329-1337
Tweaking the magnetosphere

Bruce T. Tsurutani
Walter D. Gonzalez
Research02 Jul 1992
Nature

Volume: 358, P: 26
Genome-wide association study identifies susceptibility loci for IgA nephropathy

Ali Gharavi, Rick Lifton and colleagues report a genome-wide association study for IgA nephropathy, a major cause of kidney failure. They identify five susceptibility loci.

Ali G Gharavi
Krzysztof Kiryluk
Richard P Lifton
Research13 Mar 2011
Nature Genetics

Volume: 43, P: 321-327
Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors

Annadora J. Bruce
Warren Boling
Mark P. Mattson
Research01 Jul 1996
Nature Medicine

Volume: 2, P: 788-794
Biogenic calcite structures forming in Lake Fryxell, Antarctica

Robert A. Wharton Jr
Bruce C. Parker
F. Gordon Love
Research04 Feb 1982
Nature

Volume: 295, P: 403-405
Low-energy electrodynamics of novel spin excitations in the quantum spin ice Yb₂Ti₂O₇

In geometrically frustrated magnets, long-range magnetic order is typically suppressed, whereas at the same time non-trivial spin correlations are observed. Using time-domain terahertz spectroscopy, the authors find evidence for extended quantum string-like excitations in the quantum spin ice material Yb₂Ti₂O₇.

LiDong Pan
Se Kwon Kim
N. P. Armitage
Research18 Sept 2014
Nature Communications

Volume: 5, P: 1-7
A genome-wide association study identifies susceptibility loci for Wilms tumor

Nazneen Rahman and colleagues report the results of a genome-wide association study of Wilms tumor. They show that common variants at 2p24 and 11q14 influence susceptibility to this rare pediatric kidney tumor.

Clare Turnbull
Elizabeth R Perdeaux
Nazneen Rahman
Research29 Apr 2012
Nature Genetics

Volume: 44, P: 681-684
A measure of monopole inertia in the quantum spin ice Yb₂Ti₂O₇

The dynamic susceptibility of the quantum spin ice material Yb₂Ti₂O₇ is probed by means of time-domain spectroscopic techniques, providing a handle on the conductivity of monopole excitations in this system.

LiDong Pan
N. J. Laurita
N. P. Armitage
Research21 Dec 2015
Nature Physics

Volume: 12, P: 361-366
Sex-linked markers in an Australian frog Platyplectrum ornatum (Limnodynastidae) with a small genome and homomorphic sex chromosomes

Chad Schimek
Foyez Shams
Tariq Ezaz
ResearchOpen Access03 Dec 2022
Scientific Reports

Volume: 12, P: 1-11
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

This paper shows that gut flora can influence cardiovascular disease, by metabolizing a dietary phospholipid. Using a metabolomics approach it is found that plasma levels of three metabolites of dietary phosphatidylcholine—choline, betaine and TMAO—are associated with increased risk of cardiovascular disease in humans. The gut flora is known to have a role in TMAO formation from choline, and this paper shows that dietary choline supplementation enhances macrophage foam cell formation and lesion formation in atherosclerosis-prone mice, but not if the gut flora are depleted with antibiotics.

Zeneng Wang
Elizabeth Klipfell
Stanley L. Hazen
Research06 Apr 2011
Nature

Volume: 472, P: 57-63
Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20

Justin Rubio and colleagues report results of a genome-wide association study of multiple sclerosis using cases from Australia and New Zealand. Their findings confirm several published risk loci for MS and identify two new risk loci on chromosomes 12 and 20.

Melanie Bahlo
David R Booth
Trevor J Kilpatrick
Research14 Jun 2009
Nature Genetics

Volume: 41, P: 824-828
Turbidimetric Measurement on Synchronized Salmonella typhimurium Cultures

V. G. BRUCE
K. G. LARK
O. MAALØE
Research17 Sept 1955
Nature

Volume: 176, P: 563-564
Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions

Vivianna Van Deerlin and colleagues report that common variants at 7p21 are associated with a subtype of frontotemporal lobar degeneration marked by TDP-43 inclusions. They further show that the risk alleles are associated with elevated brain expression of TMEM106B, which resides at the peak of association on 7p21.

Vivianna M Van Deerlin
Patrick M A Sleiman
Virginia M-Y Lee
Research14 Feb 2010
Nature Genetics

Volume: 42, P: 234-239
Structural basis for activation of fluorogenic dyes by an RNA aptamer lacking a G-quadruplex motif

The DIR2s RNA aptamer activates the fluorescence of cyanine dyes allowing detection of two well-resolved emission colors. Here authors solve the crystal structures of the apo and OTB-SO3 fluorophore-bound DIR2s and show how the fluorophore ligand is bound.

Sandip A. Shelke
Yaming Shao
Joseph A. Piccirilli
ResearchOpen Access31 Oct 2018
Nature Communications

Volume: 9, P: 1-10
Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction

Nona Sotoodehnia and colleagues report a meta-analysis of 14 genome-wide association studies for QRS interval, an electrocardiogram measurement of cardiac ventricular conduction. They identify 22 loci associated with QRS duration.

Nona Sotoodehnia
Aaron Isaacs
Dan E Arking
Research14 Nov 2010
Nature Genetics

Volume: 42, P: 1068-1076
Genetic insights into biological mechanisms governing human ovarian ageing

Hundreds of genetic loci associated with age at menopause, combined with experimental evidence in mice, highlight mechanisms of reproductive ageing across the lifespan.

Katherine S. Ruth
Felix R. Day
John R. B. Perry
Research04 Aug 2021
Nature

Volume: 596, P: 393-397
Genome-wide association study identifies three new melanoma susceptibility loci

Timothy Bishop and colleagues of the GenoMEL Consortium report a genome-wide association study for melanoma, identifying three new susceptibility loci.

Jennifer H Barrett
Mark M Iles
D Timothy Bishop
Research09 Oct 2011
Nature Genetics

Volume: 43, P: 1108-1113
The R72P P53 mutation is associated with familial breast cancer in Jewish women

T Ohayon
R Gershoni-Baruch
E Friedman
ResearchOpen Access01 Mar 2005
British Journal of Cancer

Volume: 92, P: 1144-1148
Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk

Richard Houlston and colleagues report a genome-wide association study for colorectal cancer. They report three loci newly associated with colorectal cancer, bringing the total number of common susceptibility loci to 20.

Malcolm G Dunlop
Sara E Dobbins
Richard S Houlston
Research27 May 2012
Nature Genetics

Volume: 44, P: 770-776
The rule of four

Guanine-rich quadruplex-forming sequences within DNA and RNA are prevalent and are suspected of regulating telomere replication, transcription and pre-mRNA splicing. The recent discovery of quadruplex-forming sequences in the 5′ untranslated regions of various proto-oncogenes suggests an important role for such sequences in inhibition of mRNA translation.

Bruce A Armitage
News & Views01 Apr 2007
Nature Chemical Biology

Volume: 3, P: 203-204
The effect of LRRK2 loss-of-function variants in humans

Analysis of large genomic datasets, including gnomAD, reveals that partial LRRK2 loss of function is not strongly associated with diseases, serving as an example of how human genetics can be leveraged for target validation in drug discovery.

Nicola Whiffin
Irina M. Armean
Daniel G. MacArthur
ResearchOpen Access27 May 2020
Nature Medicine

Volume: 26, P: 869-877
Effects of Fluoxetine on the Polysomnogram in Outpatients with Major Depression

Madhukar H Trivedi
A John Rush
Howard P Roffwarg
Research01 May 1999
Neuropsychopharmacology

Volume: 20, P: 447-459
The Effects of Fluoxetine on the Polysomnogram of Depressed Outpatients: A Pilot Study

William A. Hendrickse
Howard P. Roffwarg
A. John Rush
Research01 Apr 1994
Neuropsychopharmacology

Volume: 10, P: 85-91
A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2

Paul Pharoah and colleagues report results of the first genome-wide association study for epithelial ovarian cancer. They identify a susceptibility locus on chromosome 9p22.

Honglin Song
Susan J Ramus
Simon A Gayther
Research02 Aug 2009
Nature Genetics

Volume: 41, P: 996-1000
A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1)

David Hunter and colleagues report results of the CGEMS multistage genome-wide association study of breast cancer. They identify two new risk variants on chromosomes 1p11.2 and 14q24.1, and confirm several previously reported breast cancer risk loci.

Gilles Thomas
Kevin B Jacobs
David J Hunter
Research29 Mar 2009
Nature Genetics

Volume: 41, P: 579-584
A framework for human microbiome research

The Human Microbiome Project Consortium has established a population-scale framework to study a variety of microbial communities that exist throughout the human body, enabling the generation of a range of quality-controlled data as well as community resources.

Barbara A. Methé
Karen E. Nelson
Owen White
ResearchOpen Access13 Jun 2012
Nature

Volume: 486, P: 215-221
Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy

Colin Ross and colleagues report the association of variants in TPMT and COMT to cisplatin-induced hearing loss in children.

Colin J D Ross
Hagit Katzov-Eckert
Michael R Hayden
Research08 Nov 2009
Nature Genetics

Volume: 41, P: 1345-1349
Structure, function and diversity of the healthy human microbiome

The Human Microbiome Project Consortium reports the first results of their analysis of microbial communities from distinct, clinically relevant body habitats in a human cohort; the insights into the microbial communities of a healthy population lay foundations for future exploration of the epidemiology, ecology and translational applications of the human microbiome.

Curtis Huttenhower
Dirk Gevers
Owen White
ResearchOpen Access13 Jun 2012
Nature

Volume: 486, P: 207-214
Comparative performances of machine learning methods for classifying Crohn Disease patients using genome-wide genotyping data

Alberto Romagnoni
Simon Jégou
Pamela Whittaker
ResearchOpen Access17 Jul 2019
Scientific Reports

Volume: 9, P: 1-18
Antigene leaps forward through an open door

Blocking gene expression by interfering with translation of mRNA can be accomplished by means of antisense or short interfering RNA strategies, but more potent inhibitors would act by inhibiting transcription of genomic DNA. Two new studies show efficient inhibition of transcription using single-stranded peptide nucleic acid or double-stranded RNA targeted to the open complex formed at the transcription start site.

Bruce A Armitage
News & Views01 Sept 2005
Nature Chemical Biology

Volume: 1, P: 185-186
Polymorphisms in the sialic acid-binding immunoglobulin-like lectin-8 (Siglec-8) gene are associated with susceptibility to asthma

Pei-Song Gao
Kenichi Shimizu
Bruce S Bochner
Research20 Jan 2010
European Journal of Human Genetics

Volume: 18, P: 713-719
Defining the functional traits that drive bacterial decomposer community productivity

Rachael Evans
Anna M Alessi
Michael A Brockhurst
ResearchOpen Access21 Mar 2017
The ISME Journal

Volume: 11, P: 1680-1687
Acute Nicotine-Induced Tachyphylaxis Is Differentially Manifest in the Limbic System

Yantao Zuo
Hanbing Lu
Elliot A Stein
Research27 Jul 2011
Neuropsychopharmacology

Volume: 36, P: 2498-2512

Search

Genome-wide association study identifies novel breast cancer susceptibility loci

Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants

Tweaking the magnetosphere

Genome-wide association study identifies susceptibility loci for IgA nephropathy

Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors

Biogenic calcite structures forming in Lake Fryxell, Antarctica

Low-energy electrodynamics of novel spin excitations in the quantum spin ice Yb₂Ti₂O₇

A genome-wide association study identifies susceptibility loci for Wilms tumor

A measure of monopole inertia in the quantum spin ice Yb₂Ti₂O₇

Sex-linked markers in an Australian frog Platyplectrum ornatum (Limnodynastidae) with a small genome and homomorphic sex chromosomes

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20

Turbidimetric Measurement on Synchronized Salmonella typhimurium Cultures

Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions

Structural basis for activation of fluorogenic dyes by an RNA aptamer lacking a G-quadruplex motif

Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction

Genetic insights into biological mechanisms governing human ovarian ageing

Genome-wide association study identifies three new melanoma susceptibility loci

The R72P P53 mutation is associated with familial breast cancer in Jewish women

Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk

The rule of four

The effect of LRRK2 loss-of-function variants in humans

Effects of Fluoxetine on the Polysomnogram in Outpatients with Major Depression

The Effects of Fluoxetine on the Polysomnogram of Depressed Outpatients: A Pilot Study

A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2

A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1)

A framework for human microbiome research

Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy

Structure, function and diversity of the healthy human microbiome

Comparative performances of machine learning methods for classifying Crohn Disease patients using genome-wide genotyping data

Antigene leaps forward through an open door

Polymorphisms in the sialic acid-binding immunoglobulin-like lectin-8 (Siglec-8) gene are associated with susceptibility to asthma

Defining the functional traits that drive bacterial decomposer community productivity

Acute Nicotine-Induced Tachyphylaxis Is Differentially Manifest in the Limbic System

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