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Showing 1–5 of 5 results
Advanced filters: Author: Bruce A. Arndtsen Clear advanced filters

  • The preparation of 14C-labelled compounds is a crucial step in pharmaceutical development but typically requires using toxic, radioactive gases. Now a broadly applicable functional group metathesis reaction has been developed that forms 14C-labelled carboxylic acids in one pot, without added gases, via dynamic exchange with an easily handled carboxylic acid 14C source.

    • R. Garrison Kinney
    • José Zgheib
    • Bruce A. Arndtsen
    Research
    Nature Chemistry
    Volume: 16, P: 556-563

  • The requirement for multistep synthesis can render the fabrication of highly substituted polymers particularly troublesome. Here, the authors take advantage of metal-catalysed multicomponent polymerization to synthesize a large family of such materials with ease from single-pot reactions.

    • David C. Leitch
    • Laure V. Kayser
    • Bruce A. Arndtsen
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-8

  • Catalytic transformations that incorporate carbonyl functional groups in arene C–H bonds have remained limited, despite being attractive synthetic steps. Now, the intermolecular carbonylative coupling of a broad range of simple arenes into ketones has been developed. The reaction occurs through the palladium-catalysed generation of high-energy aroyl triflate electrophiles.

    • R. Garrison Kinney
    • Jevgenijs Tjutrins
    • Bruce A. Arndtsen
    Research
    Nature Chemistry
    Volume: 10, P: 193-199

  • Palladium-catalysed dicarbonylation using two different nucleophiles enables the selective synthesis of unsymmetrical diamides and amido esters in a single step.

    • José Zgheib
    • Bruce A. Arndtsen
    News & Views
    Nature Synthesis
    Volume: 3, P: 148-149

  • Metal-catalysed hydroformylations efficiently convert feedstock alkenes into aldehydes, though typically relatively simple ones. Now, the palladium-catalysed fragmentation of acid chlorides followed by reassembly with alkynes and silanes has been shown to form valuable, highly substituted α,β-unsaturated aldehydes.

    • José Zgheib
    • Bruce A. Arndtsen
    News & Views
    Nature Chemistry
    Volume: 13, P: 110-111