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Showing 1–2 of 2 results
Advanced filters: Author: Bruno Beaumelle Clear advanced filters

  • Phagocytic activity of macrophages is reduced in HIV-1-infected patients, but the reason for this is unknown. Here, the authors report that secreted Tat protein inhibits phagocytosis by binding to the phospholipid PI(4,5)P2and impairing the recruitment of small GTPase Cdc42 to the phagocytic cup.

    • Solène Debaisieux
    • Simon Lachambre
    • Bruno Beaumelle
    Research
    Nature Communications
    Volume: 6, P: 1-12

  • It is not clear whether and how incoming HIV-1 Tat accumulates in uninfected cells. Here, Chopard et al. show that, in uninfected cells, incoming Tat is palmitoylated on Cys31 by DHHC-20, which increases its affinity for PI(4,5)P2 and results in its accumulation at the plasma membrane.

    • Christophe Chopard
    • Phuoc Bao Viet Tong
    • Bruno Beaumelle
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-15