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Showing 1–5 of 5 results
Advanced filters: Author: Bryan Zeitler Clear advanced filters

  • Transcription activator–like effector nucleases (TALENs) are a new technology for modifying the genome at specific loci of interest. Hockemeyer et al. now demonstrate the utility of TALENs for gene targeting in human pluripotent stem cells.

    • Dirk Hockemeyer
    • Haoyi Wang
    • Rudolf Jaenisch
    Research
    Nature Biotechnology
    Volume: 29, P: 731-734

  • Genome editing mediated by zinc finger nucleases can be used to generate fluorescently labelled proteins that are expressed at endogenous levels from their native genetic loci. Applying this technology to the clathrin light chain A and dynamin-2 loci reveals that clathrin-mediated endocytosis is more regular and efficient than previously thought.

    • Jeffrey B. Doyon
    • Bryan Zeitler
    • David G. Drubin
    Research
    Nature Cell Biology
    Volume: 13, P: 331-337

  • Hockemeyer et al. demonstrate targeted genetic modification of three genes in human embryonic stem cells and induced pluripotent stem cells using zinc-finger nucleases delivered on plasmids. They use the approach to generate a reporter cell line that monitors the pluripotent state, a drug-inducible overexpression system, and a reporter cell line for a gene that is not expressed in pluripotent stem cells.

    • Dirk Hockemeyer
    • Frank Soldner
    • Rudolf Jaenisch
    Research
    Nature Biotechnology
    Volume: 27, P: 851-857