Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–7 of 7 results
Advanced filters: Author: Byron Kemper Clear advanced filters

  • Hepatic lipogenesis is a tightly regulated process, which is elevated in obesity. Here the authors report that FGF15/19, bile acid-induced gut hormones, repress lipogenic genes in the late fed-state by activating small heterodimer partner (SHP) and promoting SHP-dependent recruitment of DNA methyltransferase DNMT3A to lipogenic genes.

    • Young-Chae Kim
    • Sunmi Seok
    • Jongsook Kim Kemper
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14

  • Fasting induces hepatic autophagy to preserve energy homeostasis. Here the authors report that fasting induced fibroblast growth factor 21 signalling induces autophagy by activating lysine-specific demethylase 6B, leading to histone demethylation mediated activation of autophagy genes.

    • Sangwon Byun
    • Sunmi Seok
    • Jongsook Kim Kemper
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15

  • As signalling molecules, bile acids (BAs) can affect metabolism, but due to detergent-like properties, BA levels must be tightly regulated. Here, Kim et al.show that RanBP2, a nucleoporin, maintains BA homoeostasis through SUMOylation of Small Heterodimer Partner (SHP), an orphan nuclear receptor.

    • Dong-Hyun Kim
    • Sanghoon Kwon
    • Jongsook Kim Kemper
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-12

  • The FXR–CREB axis is identified as a key physiological switch that regulates autophagy during feeding/fasting cycles; in the fed state, the nuclear receptor FXR is shown to suppress autophagy in the liver by inhibiting autophagy-associated lipid breakdown triggered under fasting conditions by the transcriptional activator CREB.

    • Sunmi Seok
    • Ting Fu
    • Jongsook Kim Kemper
    Research
    Nature
    Volume: 516, P: 108-111

  • FXR plays an important role in bile acid homeostasis by transcriptionally modulating several enterohepatic genes, including intestinal FGF19, that repress hepatic bile acid synthesis. Here the authors show that postprandial FGF19 regulates FXR transcriptional activity via its action on the tyrosine kinase Src, which phosphorylates FXR.

    • Sangwon Byun
    • Dong-Hyun Kim
    • Jongsook Kim Kemper
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-14

  • Methyl metabolites in the one-carbon cycle, such as phosphatidylcholines and S-adenosylmethionine, play a role in hepatic triglyceride regulation. Here Kim et al. show that AhR and SHP are both involved in the expression of several key enzymes of one-carbon metabolism, with the former regulating them early after feeding and the latter inhibiting AhR at later stages.

    • Young-Chae Kim
    • Sunmi Seok
    • Jongsook Kim Kemper
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13