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Advanced filters: Author: Byung-Geon Rhee Clear advanced filters

  • Oncolytic viruses are under development for tumor treatment. David Kirn and colleagues now report their results of a randomized phase 2 dose-finding trial of JX-594, an oncolytic immunotherapeutic vaccinia virus, in patients with advanced hepatocellular carcinoma. The study shows that high-dose JX-594 was associated with significantly improved overall survival and induced radiographic responses and antitumor immunity.

    • Jeong Heo
    • Tony Reid
    • David H Kirn
    Research
    Nature Medicine
    Volume: 19, P: 329-336