Siglec-15 inhibits T cell function in the tumor microenvironment. Here, the authors solve the crystal structure of antibody-bound Siglec-15, characterize its binding mode to sialic acids, and identify sialylated CD11b as one of its binding partners on T cells.
- Maria Pia Lenza
- Leire Egia-Mendikute
- June Ereño-Orbea
