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Advanced filters: Author: Cécile Gstalder Clear advanced filters

  • MAPK-targeted therapies fail to achieve complete remission. Here, the authors show that anti-apoptosis resistance is acquired in these targeted therapies through the mRNA destabilization of NOXA which leads to dependence on MCL-1, and that sequential combination of MCL-1 inhibition with targeted therapies overcomes this resistance.

    • Joan Montero
    • Cécile Gstalder
    • Rizwan Haq
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15